Inhibits GABA-gated and glutamate-gated chloride channels in arthropod nervous systems, providing monthly flea and tick protection
At a glance
Class
Isoxazoline ectoparasiticide
Dosing
Flea and tick prevention/treatment; Demodectic mange
Duration: Year-round or seasonal; 2–3 months for demodicosis
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Absolute contraindications — do not use
Dogs with seizure history
Isoxazolines may lower seizure threshold
Puppies < 8 weeks or < 1.3 kg
Adverse effects
Common
Vomiting
Diarrhoea
Lethargy
Serious
Seizures (rare)
Tremors
Ataxia
Ectoparasite burdenSkin scraping for demodicosisNeurological signs
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Sarolaner?
Sarolaner is a isoxazoline ectoparasiticide used in pets. Inhibits GABA-gated and glutamate-gated chloride channels in arthropod nervous systems, providing monthly flea and tick protection
›What is Sarolaner used for in pets?
Sarolaner is used in veterinary medicine for: Flea and tick prevention/treatment; Demodectic mange.
›What is the Sarolaner dose for dogs?
For dogs, Sarolaner is typically dosed as follows — Flea and tick prevention/treatment; Demodectic mange: 2–4 mg/kg PO Once monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Sarolaner?
Common: Vomiting, Diarrhoea, Lethargy. Serious (call your vet immediately): Seizures (rare), Tremors, Ataxia.
›Does Sarolaner need a prescription?
Yes. Sarolaner is a prescription medication and should only be administered under veterinary supervision.
›When should Sarolaner not be used?
Do not use Sarolaner if: Cats (not approved).
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 4
Sarolaner Chewable Tablets 40 mg and 80mg SIMPARICA
M/s Zoetis India Ltd · Approved 25-02.2019
For the treatment of tick and flea infestations on dogs for 12 weeks. This veerinary medicinal product is a systemic ins
Sarolaner Chewable Tablets
M/s Zoetis India Ltd, · Approved 25-02.2019
Sarolaner kills adult fleas and is indicated for the treatment and prevention of flea infestations Ctenocephalides felis
Sarolaner Chewable Tablets
M/s Zoetis India Ltd, · Approved 25-02.2019
Sarolaner kills adult fleas and is indicated for the treatment and prevention of flea infestations Ctenocephalides felis
Selamectin and Sarolaner Topical Solution for animal use only
M/s Zoetis India Limited, 31, 3rd Floor, Kalpataru Synergy, · Approved 14.03.2026
REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. REVOLUTION PLUS kill
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database