Inhibits GABA-gated and glutamate-gated chloride channels in arthropod nervous systems, providing monthly flea and tick protection
At a glance
Class
Isoxazoline ectoparasiticide
Dosing
Flea and tick prevention/treatment; Demodectic mange
Duration: Year-round or seasonal; 2–3 months for demodicosis
Safety
Absolute contraindications — do not use
Dogs with seizure history
Isoxazolines may lower seizure threshold
Puppies < 8 weeks or < 1.3 kg
Adverse effects
Common
Vomiting
Diarrhoea
Lethargy
Serious
Seizures (rare)
Tremors
Ataxia
Ectoparasite burdenSkin scraping for demodicosisNeurological signs
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Sarolaner?
Sarolaner is a isoxazoline ectoparasiticide used in pets. Inhibits GABA-gated and glutamate-gated chloride channels in arthropod nervous systems, providing monthly flea and tick protection
›What is Sarolaner used for in pets?
Sarolaner is used in veterinary medicine for: Flea and tick prevention/treatment; Demodectic mange.
›What is the Sarolaner dose for dogs?
For dogs, Sarolaner is typically dosed as follows — Flea and tick prevention/treatment; Demodectic mange: 2–4 mg/kg PO Once monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Sarolaner?
Common: Vomiting, Diarrhoea, Lethargy. Serious (call your vet immediately): Seizures (rare), Tremors, Ataxia.
›Does Sarolaner need a prescription?
Yes. Sarolaner is a prescription medication and should only be administered under veterinary supervision.
›When should Sarolaner not be used?
Do not use Sarolaner if: Cats (not approved).
References
CDSCO approvals (India) — 4
Sarolaner Chewable Tablets 40 mg and 80mg SIMPARICA
M/s Zoetis India Ltd · Approved 25-02.2019
For the treatment of tick and flea infestations on dogs for 12 weeks. This veerinary medicinal product is a systemic ins
Sarolaner Chewable Tablets
M/s Zoetis India Ltd, · Approved 25-02.2019
Sarolaner kills adult fleas and is indicated for the treatment and prevention of flea infestations Ctenocephalides felis
Sarolaner Chewable Tablets
M/s Zoetis India Ltd, · Approved 25-02.2019
Sarolaner kills adult fleas and is indicated for the treatment and prevention of flea infestations Ctenocephalides felis
Selamectin and Sarolaner Topical Solution for animal use only
M/s Zoetis India Limited, 31, 3rd Floor, Kalpataru Synergy, · Approved 14.03.2026
REVOLUTION PLUS is indicated for the prevention of heartworm disease caused by Dirofilaria immitis. REVOLUTION PLUS kill
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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