Selectively inhibits GABA-gated chloride channels and glutamate-gated chloride channels in arthropod nerve and muscle cells, causing uncontrolled neuromuscular activity and death of fleas and ticks. High selectivity for invertebrate vs. mammalian receptors.
At a glance
Class
Isoxazoline Ectoparasiticide
Storage
Store at room temperature below 30°C
Dosing
FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1
Frequency
Monthly (q30 days)
FDA-approved for cats ≥8 weeks and ≥0
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Flea/tick burden resolutionSeizure history assessment before prescribingGI tolerance
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Lotilaner?
Lotilaner is a isoxazoline ectoparasiticide used in pets. Selectively inhibits GABA-gated chloride channels and glutamate-gated chloride channels in arthropod nerve and muscle cells, causing uncontrolled neuromuscular activity and death of fleas and ticks. High selectivity for invertebrate vs. mammalian receptors.
›What is Lotilaner used for in pets?
Lotilaner is used in veterinary medicine for: FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1; FDA-approved for cats ≥8 weeks and ≥0.
›What is the Lotilaner dose for dogs?
For dogs, Lotilaner is typically dosed as follows — FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1: 20 mg/kg PO Monthly (q30 days). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Lotilaner dose for cats?
For cats, Lotilaner is typically dosed as follows — FDA-approved for cats ≥8 weeks and ≥0: 6 mg/kg PO Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Lotilaner need a prescription?
Yes. Lotilaner is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database