Selectively inhibits GABA-gated chloride channels and glutamate-gated chloride channels in arthropod nerve and muscle cells, causing uncontrolled neuromuscular activity and death of fleas and ticks. High selectivity for invertebrate vs. mammalian receptors.
At a glance
Class
Isoxazoline Ectoparasiticide
Storage
Store at room temperature below 30°C
Dosing
FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1
Frequency
Monthly (q30 days)
FDA-approved for cats ≥8 weeks and ≥0
Safety
Flea/tick burden resolutionSeizure history assessment before prescribingGI tolerance
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Lotilaner?
Lotilaner is a isoxazoline ectoparasiticide used in pets. Selectively inhibits GABA-gated chloride channels and glutamate-gated chloride channels in arthropod nerve and muscle cells, causing uncontrolled neuromuscular activity and death of fleas and ticks. High selectivity for invertebrate vs. mammalian receptors.
›What is Lotilaner used for in pets?
Lotilaner is used in veterinary medicine for: FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1; FDA-approved for cats ≥8 weeks and ≥0.
›What is the Lotilaner dose for dogs?
For dogs, Lotilaner is typically dosed as follows — FDA-approved for flea and tick prevention/treatment in dogs ≥8 weeks and ≥1: 20 mg/kg PO Monthly (q30 days). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Lotilaner dose for cats?
For cats, Lotilaner is typically dosed as follows — FDA-approved for cats ≥8 weeks and ≥0: 6 mg/kg PO Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Lotilaner need a prescription?
Yes. Lotilaner is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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