Aminoglycoside antibiotic poorly absorbed from GI tract, providing luminal antimicrobial activity against intestinal protozoa and bacteria. Binds 30S ribosomal subunit causing protein synthesis errors. Active against Giardia, Cryptosporidium, and Entamoeba.
At a glance
Class
Aminoglycoside Antibiotic (Oral)
Storage
Store at room temperature below 25°C
Dosing
Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio
Used for feline cryptosporidiosis and giardiasis
Safety
Fecal exam post-treatmentRenal function if GI barrier compromisedClinical improvement
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Paromomycin?
Paromomycin is a aminoglycoside antibiotic (oral) used in pets. Aminoglycoside antibiotic poorly absorbed from GI tract, providing luminal antimicrobial activity against intestinal protozoa and bacteria. Binds 30S ribosomal subunit causing protein synthesis errors. Active against Giardia, Cryptosporidium, and Entamoeba.
›What is Paromomycin used for in pets?
Paromomycin is used in veterinary medicine for: Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio; Used for feline cryptosporidiosis and giardiasis.
›What is the Paromomycin dose for dogs?
For dogs, Paromomycin is typically dosed as follows — Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio: 25–30 mg/kg PO q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Paromomycin dose for cats?
For cats, Paromomycin is typically dosed as follows — Used for feline cryptosporidiosis and giardiasis: 125–165 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Paromomycin need a prescription?
Yes. Paromomycin is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →