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Paromomycin

Prescription
Aminoglycoside Antibiotic (Oral)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
2

Mechanism of action

Aminoglycoside antibiotic poorly absorbed from GI tract, providing luminal antimicrobial activity against intestinal protozoa and bacteria. Binds 30S ribosomal subunit causing protein synthesis errors. Active against Giardia, Cryptosporidium, and Entamoeba.

At a glance

Class
Aminoglycoside Antibiotic (Oral)
Schedule
Prescription
Storage
Store at room temperature below 25°C

Dosing

🐕

Dog

Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio
Dose
25–30 mg/kg
Route
PO
Frequency
q12–24h
🐈

Cat

Used for feline cryptosporidiosis and giardiasis
Dose
125–165 mg/kg
Route
PO
Frequency
q12h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature below 25°C

Safety

Monitoring parameters

Fecal exam post-treatmentRenal function if GI barrier compromisedClinical improvement
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Humatin

FAQs

Frequently asked questions

What is Paromomycin?
Paromomycin is a aminoglycoside antibiotic (oral) used in pets. Aminoglycoside antibiotic poorly absorbed from GI tract, providing luminal antimicrobial activity against intestinal protozoa and bacteria. Binds 30S ribosomal subunit causing protein synthesis errors. Active against Giardia, Cryptosporidium, and Entamoeba.
What is Paromomycin used for in pets?
Paromomycin is used in veterinary medicine for: Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio; Used for feline cryptosporidiosis and giardiasis.
What is the Paromomycin dose for dogs?
For dogs, Paromomycin is typically dosed as follows — Used for giardiasis refractory to metronidazole/fenbendazole, and cryptosporidio: 25–30 mg/kg PO q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Paromomycin dose for cats?
For cats, Paromomycin is typically dosed as follows — Used for feline cryptosporidiosis and giardiasis: 125–165 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Paromomycin need a prescription?
Yes. Paromomycin is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Aminoglycoside Antibiotic).

Amikacin
Rx
Bactericidal; binds to the 30S ribosomal subunit causing mRNA misreading and protein synthesis inhibition. Concentration-dependent killing. Active against many gram-negative bacteria including those resistant to gentamicin.
dogcat
Gentamicin
Rx
Binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA and bactericidal activity against gram-negative aerobes
dogcat
Gentamicin (Systemic)
Rx
Bactericidal; binds 30S ribosomal subunit causing mRNA misreading and protein synthesis inhibition. Concentration-dependent killing with significant post-antibiotic effect. Active against aerobic gram-negative bacteria including Pseudomonas.
dogcat
Neomycin
Rx
Bactericidal antibiotic that binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis. Poorly absorbed from the GI tract after oral administration.
dogcat
Tobramycin
Rx
Binds irreversibly to the 30S ribosomal subunit, inhibiting bacterial protein synthesis; concentration-dependent bactericidal activity, particularly effective against Pseudomonas aeruginosa
dogcat
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