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Neomycin

Prescription

Aminoglycoside Antibiotic

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

2 available

Interactions

3 documented

Formulations

Mechanism of action

Bactericidal antibiotic that binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis. Poorly absorbed from the GI tract after oral administration.

At a glance

Class

Aminoglycoside Antibiotic

Schedule

Prescription

Storage

Store at room temperature, protect from light

Dosing

🐕

Dog

Systemic absorption minimal with oral route

Dose

20 mg/kg

Route

PO, Topical

Frequency

q12h

🐈

Cat

Use with caution; nephrotoxicity possible if absorbed systemically

Dose

20 mg/kg

Route

PO, Topical

Frequency

q12h

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 3

Strength

—

Strength

—

Strength

—

Storage

Store at room temperature, protect from light

Safety

Monitoring parameters

Renal function (BUN, creatinine)Hearing if prolonged useGI function

Educational reference only

Interactions

Major — 1

Furosemide

major

Furosemide increases aminoglycoside nephro- and ototoxicity by concentrating drug in renal tubules and inner ear.

Management: Avoid concurrent systemic use. Oral neomycin (for hepatic encephalopathy) has minimal systemic absorption and lower risk.

Moderate — 2

Digoxin

moderate

Oral neomycin reduces digoxin absorption by 20-30% by disrupting intestinal flora that partially metabolizes digoxin and by direct binding.

Management: Monitor digoxin levels during neomycin courses. May need temporary digoxin dose increase.

Lactulose

moderate

Both used for hepatic encephalopathy (lactulose: acidifies colon trapping NH3; neomycin: kills ammonia-producing bacteria). Neomycin may also kill bacteria that ferment lactulose to lactic acid, potentially reducing lactulose efficacy.

Management: Combination is clinically used but evidence of antagonism exists. Monitor ammonia levels and clinical response. Some clinicians avoid combining.

Educational reference only

Brands

Other markets

Biosol

Neomix

FAQs

Frequently asked questions

›What is Neomycin?

Neomycin is a aminoglycoside antibiotic used in pets. Bactericidal antibiotic that binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibiting protein synthesis. Poorly absorbed from the GI tract after oral administration.

›What is Neomycin used for in pets?

Neomycin is used in veterinary medicine for: Systemic absorption minimal with oral route; Use with caution; nephrotoxicity possible if absorbed systemically.

›What is the Neomycin dose for dogs?

For dogs, Neomycin is typically dosed as follows — Systemic absorption minimal with oral route: 20 mg/kg PO/Topical q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Neomycin dose for cats?

For cats, Neomycin is typically dosed as follows — Use with caution; nephrotoxicity possible if absorbed systemically: 20 mg/kg PO/Topical q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Neomycin need a prescription?

Yes. Neomycin is a prescription medication and should only be administered under veterinary supervision.

Educational reference only