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Amikacin

Prescription

Aminoglycoside Antibiotic

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

2 available

Interactions

1 documented

Formulations

Mechanism of action

Bactericidal; binds to the 30S ribosomal subunit causing mRNA misreading and protein synthesis inhibition. Concentration-dependent killing. Active against many gram-negative bacteria including those resistant to gentamicin.

At a glance

Class

Aminoglycoside Antibiotic

Schedule

Prescription

Storage

Store at room temperature 15–30°C; stable for 24h at room temperature after dilution

Dosing

🐕

Dog

Once-daily dosing preferred to reduce nephrotoxicity

Dose

15–30 mg/kg

Route

IV, IM, SQ

Frequency

q24h

🐈

Cat

Cats are highly susceptible to aminoglycoside nephrotoxicity; use lowest effecti

Dose

10–14 mg/kg

Route

IV, IM, SQ

Frequency

q24h

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Store at room temperature 15–30°C; stable for 24h at room temperature after dilution

Safety

Monitoring parameters

BUN, creatinine, urinalysis (casts) before and during therapySerum drug levels if availableVestibular signs

Educational reference only

Interactions

Major — 1

Furosemide

major

Furosemide increases aminoglycoside nephro- and ototoxicity by concentrating drug in renal tubules and inner ear.

Management: Avoid concurrent use. If unavoidable, maintain hydration, monitor renal function, and monitor for vestibular signs.

Educational reference only

Brands

Other markets

Amiglyde-V

Amikin

FAQs

Frequently asked questions

›What is Amikacin?

Amikacin is a aminoglycoside antibiotic used in pets. Bactericidal; binds to the 30S ribosomal subunit causing mRNA misreading and protein synthesis inhibition. Concentration-dependent killing. Active against many gram-negative bacteria including those resistant to gentamicin.

›What is Amikacin used for in pets?

Amikacin is used in veterinary medicine for: Once-daily dosing preferred to reduce nephrotoxicity; Cats are highly susceptible to aminoglycoside nephrotoxicity; use lowest effecti.

›What is the Amikacin dose for dogs?

For dogs, Amikacin is typically dosed as follows — Once-daily dosing preferred to reduce nephrotoxicity: 15–30 mg/kg IV/IM/SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Amikacin dose for cats?

For cats, Amikacin is typically dosed as follows — Cats are highly susceptible to aminoglycoside nephrotoxicity; use lowest effecti: 10–14 mg/kg IV/IM/SQ q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Amikacin need a prescription?

Yes. Amikacin is a prescription medication and should only be administered under veterinary supervision.

Educational reference only