Activates glutamate-gated chloride channels in invertebrate nerve and muscle cells, causing paralysis and death of parasites; effective against heartworm larvae, roundworms, and hookworms
At a glance
Class
Macrocyclic lactone (milbemycin) antiparasitic
Storage
Store below 25°C, protect from light and moisture
Dosing
Heartworm prevention / Intestinal nematodes
Duration: Year-round prevention
Demodex (generalized demodicosis)
Duration: Until 2 consecutive negative skin scrapings 1 month apart
Intestinal parasites
Frequency
Monthly or as needed
Duration: Monthly prevention
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Absolute contraindications — do not use
MDR1 mutation (homozygous)
At high doses (>0.5 mg/kg); safe at heartworm prevention dose
CollieShetland SheepdogAustralian ShepherdOld English Sheepdog
Adverse effects
Common
Vomiting
Diarrhoea
Lethargy (transient)
Serious
Neurotoxicity in MDR1-mutant dogs at high doses (ataxia, tremors, seizures)
Hypersalivation
Heartworm antigen test (annual)Fecal examinationSkin scrapings (demodicosis)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Milbemycin Oxime?
Milbemycin Oxime is a macrocyclic lactone (milbemycin) antiparasitic used in pets. Activates glutamate-gated chloride channels in invertebrate nerve and muscle cells, causing paralysis and death of parasites; effective against heartworm larvae, roundworms, and hookworms
›What is Milbemycin Oxime used for in pets?
Milbemycin Oxime is used in veterinary medicine for: Heartworm prevention / Intestinal nematodes; Demodex (generalized demodicosis); Intestinal parasites.
›What is the Milbemycin Oxime dose for dogs?
For dogs, Milbemycin Oxime is typically dosed as follows — Heartworm prevention / Intestinal nematodes: 0.5–1 mg/kg PO Monthly; Demodex (generalized demodicosis): 1–2 mg/kg PO SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Milbemycin Oxime dose for cats?
For cats, Milbemycin Oxime is typically dosed as follows — Intestinal parasites: 2–4 mg/kg PO Monthly or as needed. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Milbemycin Oxime?
Common: Vomiting, Diarrhoea, Lethargy (transient). Serious (call your vet immediately): Neurotoxicity in MDR1-mutant dogs at high doses (ataxia, tremors, seizures), Hypersalivation.
›Does Milbemycin Oxime need a prescription?
Yes. Milbemycin Oxime is a prescription medication and should only be administered under veterinary supervision.
›When should Milbemycin Oxime not be used?
Do not use Milbemycin Oxime if: MDR1 mutation (homozygous).
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 5
Milbemycin Oxime …….2.5mg/12.5mg Praziquantel …………………..25mg/125mg Tablets (Veter
M/s. Elanco India Pvt. Ltd. · Approved 12.09.2017
Treatment of nematode and cestode infection in dogs.
Fixed dose combination of milbemycin oxime and praziquantel tablets milpro cats
M/s Virbac Animal Health India Pvt Ltd · Approved 09.09.2021
Treatment of mixed infectious by immature and adult cestodes tapeworms and adult nematodes roundworms of the folloing sp
Milbemycin oxime and praziquantel tablets milpro
M/s Virbac Animal Health India pvt ltd., · Approved 21.12.2021
Treatment of mixed infections by adult cestodes tapeworms an nematodes roundworms of the following species cestodes dipy
Afoxolaner and milbemycin Oxime Chewable tablets (Brand name Nexgard Spectra)
M/s Boehringer Ingelheim India Pvt. Ltd., · Approved 02.02.2023
for the treatment of flea and tick infestations in dogs when the concurrent prevention of heartworm disease (Dirofilaria
“FDC of Lotilaner and Milbemycin Oxime 56.25mg/2.11 mg, 112.5mg/4.22mg, 225mg/8.
M/s Elanco India Pvt. Ltd. · Approved 02.08.2024
For use in dogs with, or at risk from, mixed infestations/infctions of ticks, fleas, gastrointestinal nematodes, heartwo
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database