Binds to glutamate-gated chloride channels in nematode and arthropod nerve and muscle cells, causing prolonged opening and irreversible hyperpolarization, resulting in paralysis and death of parasites. Does not cross intact mammalian BBB.
At a glance
Class
Macrocyclic Lactone (Avermectin)
Storage
Store at room temperature below 30°C; protect from light
Dosing
Off-label for generalized demodicosis (daily oral)
Frequency
q24h (demodicosis); once (ectoparasites)
Off-label for feline ear mites, demodicosis
Frequency
Once; repeat in 2–4 weeks if needed
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
MDR1 genetic testing before use in herding breedsNeurological status during dose escalationSkin scrapings monthly (demodicosis)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Doramectin?
Doramectin is a macrocyclic lactone (avermectin) used in pets. Binds to glutamate-gated chloride channels in nematode and arthropod nerve and muscle cells, causing prolonged opening and irreversible hyperpolarization, resulting in paralysis and death of parasites. Does not cross intact mammalian BBB.
›What is Doramectin used for in pets?
Doramectin is used in veterinary medicine for: Off-label for generalized demodicosis (daily oral); Off-label for feline ear mites, demodicosis.
›What is the Doramectin dose for dogs?
For dogs, Doramectin is typically dosed as follows — Off-label for generalized demodicosis (daily oral): 0.3–0.6 mg/kg PO/SQ q24h (demodicosis); once (ectoparasites). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Doramectin dose for cats?
For cats, Doramectin is typically dosed as follows — Off-label for feline ear mites, demodicosis: 0.2 mg/kg SQ Once; repeat in 2–4 weeks if needed. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Doramectin need a prescription?
Yes. Doramectin is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 2
Doramectin 1% Injectible solution
M/s Pfizer Ltd · Approved 17.10.1997
Treatment and control of gastrointestinal round worms lung worms eye worm screw worms in cattle
Doramectin 1%
M/s Pfizer · Approved 03.10.2000
For control of GI round worm, eye worm screw worms in sheep and swin
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database