Binds to glutamate-gated chloride channels in nematode and arthropod nerve and muscle cells, causing prolonged opening and irreversible hyperpolarization, resulting in paralysis and death of parasites. Does not cross intact mammalian BBB.
At a glance
Class
Macrocyclic Lactone (Avermectin)
Storage
Store at room temperature below 30°C; protect from light
Dosing
Off-label for generalized demodicosis (daily oral)
Frequency
q24h (demodicosis); once (ectoparasites)
Off-label for feline ear mites, demodicosis
Frequency
Once; repeat in 2–4 weeks if needed
Safety
MDR1 genetic testing before use in herding breedsNeurological status during dose escalationSkin scrapings monthly (demodicosis)
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Doramectin?
Doramectin is a macrocyclic lactone (avermectin) used in pets. Binds to glutamate-gated chloride channels in nematode and arthropod nerve and muscle cells, causing prolonged opening and irreversible hyperpolarization, resulting in paralysis and death of parasites. Does not cross intact mammalian BBB.
›What is Doramectin used for in pets?
Doramectin is used in veterinary medicine for: Off-label for generalized demodicosis (daily oral); Off-label for feline ear mites, demodicosis.
›What is the Doramectin dose for dogs?
For dogs, Doramectin is typically dosed as follows — Off-label for generalized demodicosis (daily oral): 0.3–0.6 mg/kg PO/SQ q24h (demodicosis); once (ectoparasites). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Doramectin dose for cats?
For cats, Doramectin is typically dosed as follows — Off-label for feline ear mites, demodicosis: 0.2 mg/kg SQ Once; repeat in 2–4 weeks if needed. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Doramectin need a prescription?
Yes. Doramectin is a prescription medication and should only be administered under veterinary supervision.
References
CDSCO approvals (India) — 2
Doramectin 1% Injectible solution
M/s Pfizer Ltd · Approved 17.10.1997
Treatment and control of gastrointestinal round worms lung worms eye worm screw worms in cattle
Doramectin 1%
M/s Pfizer · Approved 03.10.2000
For control of GI round worm, eye worm screw worms in sheep and swin
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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