Binds to DNA minor groove and inhibits polyamine synthesis in protozoa, disrupting nucleic acid metabolism. Also concentrates in liver and kidney of protozoa, interfering with aerobic glycolysis. Active against Babesia, Hepatozoon, and Ehrlichia.
At a glance
Class
Antiprotozoal (Carbanilide Derivative)
Storage
Store at room temperature below 25°C, protect from light
Dosing
Treatment of choice for Babesia canis (large Babesia)
Frequency
Once or q14 days x 2–3 doses
Off-label for feline babesiosis and cytauxzoonosis
Safety
Pre-treat with atropineObserve 30 min post-injection for cholinergic signsHepatic and renal functionBlood smear for parasite clearance at 2 weeks
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Imidocarb Dipropionate?
Imidocarb Dipropionate is a antiprotozoal (carbanilide derivative) used in pets. Binds to DNA minor groove and inhibits polyamine synthesis in protozoa, disrupting nucleic acid metabolism. Also concentrates in liver and kidney of protozoa, interfering with aerobic glycolysis. Active against Babesia, Hepatozoon, and Ehrlichia.
›What is Imidocarb Dipropionate used for in pets?
Imidocarb Dipropionate is used in veterinary medicine for: Treatment of choice for Babesia canis (large Babesia); Off-label for feline babesiosis and cytauxzoonosis.
›What is the Imidocarb Dipropionate dose for dogs?
For dogs, Imidocarb Dipropionate is typically dosed as follows — Treatment of choice for Babesia canis (large Babesia): 5–6 mg/kg IM/SQ Once or q14 days x 2–3 doses. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Imidocarb Dipropionate dose for cats?
For cats, Imidocarb Dipropionate is typically dosed as follows — Off-label for feline babesiosis and cytauxzoonosis: 3.5 mg/kg IM Once. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Imidocarb Dipropionate need a prescription?
Yes. Imidocarb Dipropionate is a prescription medication and should only be administered under veterinary supervision.
References
CDSCO approvals (India) — 2
Imidocarb Dipropionate Injection (Imizol)
M/s Intervet India pvt. Ltd., · Approved 21.01.2022
for the treatment and prevention of Babesiosis in cattle and horses. For the treatment of bovine anaplasmosis. For the t
Imidocarb Dipropionate Aqueous Injection 120 Mg/ml
M/s Intracin Pharmaceuticals Pvt. Ltd., · Approved 25.02.2022
For treatment of babesiosis in cattle sheep, horses and dogs and iof anaplasmosis in cattle. Treatemnt of ehrlichiosis i
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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