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Atovaquone

Prescription
Antiprotozoal (Hydroxynaphthoquinone)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
2

Mechanism of action

Selectively inhibits mitochondrial electron transport at complex III in protozoa, collapsing the mitochondrial membrane potential and blocking pyrimidine biosynthesis. Active against Babesia, Pneumocystis, Toxoplasma, and Hepatozoon.

At a glance

Class
Antiprotozoal (Hydroxynaphthoquinone)
Schedule
Prescription
Storage
Store at room temperature 15–25°C; do not freeze oral suspension

Dosing

🐕

Dog

Used for Babesia gibsoni (combined with azithromycin 10 mg/kg q24h)
Dose
13.3 mg/kg
Route
PO
Frequency
q8h
🐈

Cat

Used for cytauxzoonosis and babesiosis in cats (with azithromycin)
Dose
15 mg/kg
Route
PO
Frequency
q12h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature 15–25°C; do not freeze oral suspension

Safety

Monitoring parameters

Babesia/Hepatozoon PCR post-treatmentHepatic enzymesGI tolerancePCV/hematocrit
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Mepron
Malarone (with proguanil)

FAQs

Frequently asked questions

What is Atovaquone?
Atovaquone is a antiprotozoal (hydroxynaphthoquinone) used in pets. Selectively inhibits mitochondrial electron transport at complex III in protozoa, collapsing the mitochondrial membrane potential and blocking pyrimidine biosynthesis. Active against Babesia, Pneumocystis, Toxoplasma, and Hepatozoon.
What is Atovaquone used for in pets?
Atovaquone is used in veterinary medicine for: Used for Babesia gibsoni (combined with azithromycin 10 mg/kg q24h); Used for cytauxzoonosis and babesiosis in cats (with azithromycin).
What is the Atovaquone dose for dogs?
For dogs, Atovaquone is typically dosed as follows — Used for Babesia gibsoni (combined with azithromycin 10 mg/kg q24h): 13.3 mg/kg PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Atovaquone dose for cats?
For cats, Atovaquone is typically dosed as follows — Used for cytauxzoonosis and babesiosis in cats (with azithromycin): 15 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Atovaquone need a prescription?
Yes. Atovaquone is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Antiprotozoal).

Diminazene
Rx
Aromatic diamidine compound that binds to kinetoplast DNA (kDNA) minor groove of trypanosomes and Babesia, disrupting DNA replication and transcription. Also inhibits aerobic glycolysis and delta-aminolevulinic acid synthetase in protozoa.
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Imidocarb Dipropionate
Rx
Binds to DNA minor groove and inhibits polyamine synthesis in protozoa, disrupting nucleic acid metabolism. Also concentrates in liver and kidney of protozoa, interfering with aerobic glycolysis. Active against Babesia, Hepatozoon, and Ehrlichia.
dogcat
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