Binds to nicotinic acetylcholine receptors in insect nervous system with much higher affinity than mammalian receptors (selective toxicity). Causes sustained depolarization, paralysis, and death of fleas and lice within hours of contact.
At a glance
Class
Neonicotinoid Insecticide
Storage
Store at room temperature below 30°C
Dosing
Applied to skin between shoulder blades
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Flea burden assessmentApplication site for irritation
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
Brands
Other markets
Advantage Multi (with moxidectin)
FAQs
Frequently asked questions
›What is Imidacloprid (Systemic)?
Imidacloprid (Systemic) is a neonicotinoid insecticide used in pets. Binds to nicotinic acetylcholine receptors in insect nervous system with much higher affinity than mammalian receptors (selective toxicity). Causes sustained depolarization, paralysis, and death of fleas and lice within hours of contact.
›What is Imidacloprid (Systemic) used for in pets?
Imidacloprid (Systemic) is used in veterinary medicine for: Applied to skin between shoulder blades; Same application as dogs.
›What is the Imidacloprid (Systemic) dose for dogs?
For dogs, Imidacloprid (Systemic) is typically dosed as follows — Applied to skin between shoulder blades: 10 mg/kg Topical (spot-on) Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Imidacloprid (Systemic) dose for cats?
For cats, Imidacloprid (Systemic) is typically dosed as follows — Same application as dogs: 10 mg/kg Topical Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Imidacloprid (Systemic) need a prescription?
Yes. Imidacloprid (Systemic) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 3
Imidacloprid cutaneous solution
M/s Bayer India Limited · Approved 23.03.2001
prevention and treatment of flee infestation on dogs.
Imidacloprid 10% + Moxidectin 1.0% & 2.5% Topical solution vet
M/s Bayer polychem ltd thane · Approved 03.10.2009
For the treatment and prevention of flea infestations prevention of heartworm disease and treatment of infections with g
Imidacloprid+ Moxidectin spot on solution
M/s Bayer Pharma · Approved 05.04.2011
For the treatment and preivention of flea infestation treatment of ear mite infestation, prevention of heartworm disease
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database