Home/Medicines/Imidacloprid
All medicines

Imidacloprid

CDSCO approved
Neonicotinoid insecticide
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
4

Mechanism of action

Binds to insect nicotinic acetylcholine receptors, causing continuous nerve stimulation, paralysis, and death of fleas and lice; minimal mammalian receptor affinity

At a glance

Class
Neonicotinoid insecticide
Schedule
OTC
Storage
Store below 25°C, protect from heat sources
CDSCO (India)
Vet-approved — 2002-01

Dosing

🐕

Dog

Flea treatment and prevention
Dose
10–25 mg/kg
Route
Topical
Frequency
Monthly
Max dose
1000 mg
Duration: Monthly as needed; year-round in endemic areas
🐈

Cat

Flea treatment and prevention
Dose
10–20 mg/kg
Route
Topical
Frequency
Monthly
Max dose
100 mg
Duration: Monthly as needed
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

🧴

Spot-on solution — 4

Strength
40mg (small cat)
Available in India
Strength
100mg (small dog)
Available in India
Strength
250mg (medium dog)
Available in India
Strength
400mg (large dog)
Available in India

Storage

Store below 25°C, protect from heat sources

Safety

Absolute contraindications — do not use

  • Oral ingestion (topical product only)
    GI signs if ingested

Use with caution

  • Kittens under 8 weeks
    Use with caution

Adverse effects

Common
Transient skin irritation at application site
Temporary hair loss at site
Serious
Neurological signs if ingested orally (tremors, salivation)
Allergic dermatitis (rare)

Monitoring parameters

Flea burden assessmentSkin at application site
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

International

Advantage
Bayer/Elanco

India

Fiprofort Plus (with fipronil)
Cipla
Imidavet
Intas

FAQs

Frequently asked questions

What is Imidacloprid?
Imidacloprid is a neonicotinoid insecticide used in pets. Binds to insect nicotinic acetylcholine receptors, causing continuous nerve stimulation, paralysis, and death of fleas and lice; minimal mammalian receptor affinity
What is Imidacloprid used for in pets?
Imidacloprid is used in veterinary medicine for: Flea treatment and prevention.
What is the Imidacloprid dose for dogs?
For dogs, Imidacloprid is typically dosed as follows — Flea treatment and prevention: 10–25 mg/kg Topical Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Imidacloprid dose for cats?
For cats, Imidacloprid is typically dosed as follows — Flea treatment and prevention: 10–20 mg/kg Topical Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What are the side effects of Imidacloprid?
Common: Transient skin irritation at application site, Temporary hair loss at site. Serious (call your vet immediately): Neurological signs if ingested orally (tremors, salivation), Allergic dermatitis (rare).
Does Imidacloprid need a prescription?
Imidacloprid is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
When should Imidacloprid not be used?
Do not use Imidacloprid if: Oral ingestion (topical product only).
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Neonicotinoid insecticide).

Imidacloprid (Systemic)
Rx
Binds to nicotinic acetylcholine receptors in insect nervous system with much higher affinity than mammalian receptors (selective toxicity). Causes sustained depolarization, paralysis, and death of fleas and lice within hours of contact.
dogcat
Nitenpyram
Acts on nicotinic acetylcholine receptors in insect neurons, causing rapid paralysis and death of adult fleas within 30 minutes
dogcat
Need help? 💬
Chat with us on WhatsApp