Inhibits bacterial cell wall synthesis; broader gram-negative spectrum than first-generation cephalosporins
At a glance
Class
Third-generation cephalosporin antibiotic
Dosing
Skin and soft tissue infections
Duration: 5-7 days (superficial) to 28 days (deep)
Urinary tract infections
Duration: 10-14 days
Skin and urinary infections
Duration: 5-14 days
Safety
Absolute contraindications — do not use
Adverse effects
Common
Vomiting
Diarrhoea
Decreased appetite
Serious
Anaphylaxis (rare)
Pseudomembranous colitis
Clinical responseGI toleranceRenal function in compromised patients
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Cefpodoxime Proxetil?
Cefpodoxime Proxetil is a third-generation cephalosporin antibiotic used in pets. Inhibits bacterial cell wall synthesis; broader gram-negative spectrum than first-generation cephalosporins
›What is Cefpodoxime Proxetil used for in pets?
Cefpodoxime Proxetil is used in veterinary medicine for: Skin and soft tissue infections; Urinary tract infections; Skin and urinary infections.
›What is the Cefpodoxime Proxetil dose for dogs?
For dogs, Cefpodoxime Proxetil is typically dosed as follows — Skin and soft tissue infections: 5–10 mg/kg PO SID; Urinary tract infections: 5–10 mg/kg PO SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Cefpodoxime Proxetil dose for cats?
For cats, Cefpodoxime Proxetil is typically dosed as follows — Skin and urinary infections: 5–10 mg/kg PO SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Cefpodoxime Proxetil?
Common: Vomiting, Diarrhoea, Decreased appetite. Serious (call your vet immediately): Anaphylaxis (rare), Pseudomembranous colitis.
›Does Cefpodoxime Proxetil need a prescription?
Yes. Cefpodoxime Proxetil is a prescription medication and should only be administered under veterinary supervision.
›When should Cefpodoxime Proxetil not be used?
Do not use Cefpodoxime Proxetil if: Known cephalosporin hypersensitivity.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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