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Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin)

Ophthalmic Combination Antibiotic
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
2

Mechanism of action

Triple combination: neomycin (30S ribosome — gram-negative), polymyxin B (cell membrane disruption — gram-negative), bacitracin (cell wall synthesis — gram-positive). Together cover most common superficial ocular pathogens.

At a glance

Class
Ophthalmic Combination Antibiotic
Schedule
OTC
Storage
Store at room temperature below 25°C

Dosing

🐕

Dog

Used for bacterial conjunctivitis, superficial corneal ulcers, and prophylaxis p
Dose
Route
Ophthalmic
Frequency
q4–8h
🐈

Cat

Same as dogs
Dose
Route
Ophthalmic
Frequency
q4–8h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature below 25°C

Safety

Monitoring parameters

Clinical response at 5–7 daysPeriocular skin for contact dermatitis (neomycin)Switch to non-neomycin product if sensitization occurs
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Neo-Poly-Bac Ophthalmic
Neosporin Ophthalmic

FAQs

Frequently asked questions

What is Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin)?
Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) is a ophthalmic combination antibiotic used in pets. Triple combination: neomycin (30S ribosome — gram-negative), polymyxin B (cell membrane disruption — gram-negative), bacitracin (cell wall synthesis — gram-positive). Together cover most common superficial ocular pathogens.
What is Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) used for in pets?
Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) is used in veterinary medicine for: Used for bacterial conjunctivitis, superficial corneal ulcers, and prophylaxis p; Same as dogs.
What is the Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) dose for dogs?
For dogs, Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) is typically dosed as follows — Used for bacterial conjunctivitis, superficial corneal ulcers, and prophylaxis p: undefined undefined Ophthalmic q4–8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) dose for cats?
For cats, Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) is typically dosed as follows — Same as dogs: undefined undefined Ophthalmic q4–8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) need a prescription?
Triple Antibiotic Ophthalmic (Neomycin/Polymyxin B/Bacitracin) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Ophthalmic Combination Antibiotic).

Oxytetracycline/Polymyxin B Ophthalmic
Oxytetracycline inhibits bacterial protein synthesis (30S ribosomal subunit) covering gram-positive, Chlamydophila, and Mycoplasma. Polymyxin B disrupts gram-negative cell membranes. Together provide broad-spectrum coverage for ocular infections.
dogcat
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