Home/Medicines/Tranexamic Acid

Tranexamic Acid

Prescription

Antifibrinolytic agent

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

4 available

Interactions

1 documented

Formulations

Mechanism of action

Synthetic lysine analog that competitively inhibits plasminogen activation by blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and thereby inhibiting fibrinolysis and stabilizing blood clots

At a glance

Class

Antifibrinolytic agent

Schedule

Prescription

Storage

Below 25°C, protect from light

Dosing

🐕

Dog

Hemorrhage (surgical, traumatic), hemoabdomen adjunct, DIC adjunct

Dose

10–25 mg/kg

Route

IV (slow), PO

Frequency

BID to TID

Max dose

1000 mg/dose; 3000 mg/day

Duration: 3–5 days or until hemorrhage controlled

🐈

Cat

Hemorrhage, hyphema

Dose

10–20 mg/kg

Route

IV (slow), PO

Frequency

BID to TID

Max dose

250 mg/dose; 750 mg/day

Duration: 3–5 days

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Tablet — 1

Strength

500mg

Available in India

💉

Injectable solution — 1

Strength

100mg/mL

Available in India

Storage

Below 25°C, protect from light

Safety

Absolute contraindications — do not use

Active thromboembolic disease
Antifibrinolytic may worsen existing thrombosis

Use with caution

DIC (disseminated intravascular coagulation)
Use only in hyperfibrinolytic phase with hematologist guidance
Renal impairment
Renally excreted; dose reduction needed

Adverse effects

Common

GI upset (nausea, vomiting, diarrhea)

Serious

Thromboembolism

Seizures (rare, high IV doses)

Renal cortical necrosis (rare)

Monitoring parameters

Coagulation parameters (PT, aPTT, fibrinogen)Signs of thromboembolismHemorrhage controlRenal function

Educational reference only

Interactions

Major — 1

Estradiol

major

Estrogens increase clotting factor synthesis and reduce antithrombin III. Tranexamic acid inhibits fibrinolysis. Combined: significantly increased thromboembolism risk.

Management: Avoid combination. If antifibrinolytic needed in patient on estrogen, monitor closely for thrombosis.

Educational reference only

Brands

International

Cyklokapron

Pfizer

Lysteda

Ferring

India

Tranexa

Sun Pharma

Pause

Cipla

FAQs

Frequently asked questions

›What is Tranexamic Acid?

Tranexamic Acid is a antifibrinolytic agent used in pets. Synthetic lysine analog that competitively inhibits plasminogen activation by blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and thereby inhibiting fibrinolysis and stabilizing blood clots

›What is Tranexamic Acid used for in pets?

Tranexamic Acid is used in veterinary medicine for: Hemorrhage (surgical, traumatic), hemoabdomen adjunct, DIC adjunct; Hemorrhage, hyphema.

›What is the Tranexamic Acid dose for dogs?

For dogs, Tranexamic Acid is typically dosed as follows — Hemorrhage (surgical, traumatic), hemoabdomen adjunct, DIC adjunct: 10–25 mg/kg IV (slow)/PO BID to TID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Tranexamic Acid dose for cats?

For cats, Tranexamic Acid is typically dosed as follows — Hemorrhage, hyphema: 10–20 mg/kg IV (slow)/PO BID to TID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What are the side effects of Tranexamic Acid?

Common: GI upset (nausea, vomiting, diarrhea). Serious (call your vet immediately): Thromboembolism, Seizures (rare, high IV doses), Renal cortical necrosis (rare).

›Does Tranexamic Acid need a prescription?

Yes. Tranexamic Acid is a prescription medication and should only be administered under veterinary supervision.

›When should Tranexamic Acid not be used?

Do not use Tranexamic Acid if: Active thromboembolic disease.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Antifibrinolytic agent).

Aminocaproic Acid

Competitively inhibits plasminogen activation by blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and inhibiting fibrinolysis. Also used for degenerative myelopathy.

dogcat