Competitively inhibits plasminogen activation by blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and inhibiting fibrinolysis. Also used for degenerative myelopathy.
At a glance
Class
Antifibrinolytic Agent
Storage
Store at room temperature below 30°C
Dosing
Used for hemorrhage due to hyperfibrinolysis and DIC-associated bleeding
Frequency
q8h (PO); CRI (IV)
Safety
Coagulation panelCPK for myopathy with prolonged useRenal function
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Aminocaproic Acid?
Aminocaproic Acid is a antifibrinolytic agent used in pets. Competitively inhibits plasminogen activation by blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and inhibiting fibrinolysis. Also used for degenerative myelopathy.
›What is Aminocaproic Acid used for in pets?
Aminocaproic Acid is used in veterinary medicine for: Used for hemorrhage due to hyperfibrinolysis and DIC-associated bleeding; Rarely used in cats.
›What is the Aminocaproic Acid dose for dogs?
For dogs, Aminocaproic Acid is typically dosed as follows — Used for hemorrhage due to hyperfibrinolysis and DIC-associated bleeding: 15–40 mg/kg PO/IV q8h (PO); CRI (IV). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Aminocaproic Acid dose for cats?
For cats, Aminocaproic Acid is typically dosed as follows — Rarely used in cats: 15–20 mg/kg PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Aminocaproic Acid need a prescription?
Yes. Aminocaproic Acid is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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