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Tolfenamic Acid

Prescription

NSAID (Fenamate Class)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

2 available

Interactions

2 documented

Formulations

Mechanism of action

Non-selective COX-1 and COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Additionally inhibits prostaglandin receptor binding beyond simple synthesis inhibition.

At a glance

Class

NSAID (Fenamate Class)

Schedule

Prescription

Storage

Store at room temperature below 25°C, protect from moisture

Dosing

🐕

Dog

Short course NSAID for pain and inflammation

Dose

4 mg/kg

Route

PO, SQ

Frequency

q24h x 3–5 days

🐈

Cat

One of the licensed NSAIDs for short-term pain management in cats in Europe

Dose

4 mg/kg

Route

PO, SQ

Frequency

q24h x 3 days

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength

—

Strength

—

Storage

Store at room temperature below 25°C, protect from moisture

Safety

Monitoring parameters

Renal functionGI signsHepatic enzymes with repeated courses

Educational reference only

Interactions

Contraindicated — 1

Meloxicam

contraindicated

Two NSAIDs: synergistic GI and renal toxicity.

Management: NEVER combine. Allow 5-7 day washout.

Major — 1

Prednisolone

major

NSAID + corticosteroid: additive GI ulceration risk.

Management: Do not combine. Allow 3-5 day washout when switching.

Educational reference only

Brands

Other markets

Tolfedine

Clotam

FAQs

Frequently asked questions

›What is Tolfenamic Acid?

Tolfenamic Acid is a nsaid (fenamate class) used in pets. Non-selective COX-1 and COX-2 inhibitor with anti-inflammatory, analgesic, and antipyretic properties. Additionally inhibits prostaglandin receptor binding beyond simple synthesis inhibition.

›What is Tolfenamic Acid used for in pets?

Tolfenamic Acid is used in veterinary medicine for: Short course NSAID for pain and inflammation; One of the licensed NSAIDs for short-term pain management in cats in Europe.

›What is the Tolfenamic Acid dose for dogs?

For dogs, Tolfenamic Acid is typically dosed as follows — Short course NSAID for pain and inflammation: 4 mg/kg PO/SQ q24h x 3–5 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Tolfenamic Acid dose for cats?

For cats, Tolfenamic Acid is typically dosed as follows — One of the licensed NSAIDs for short-term pain management in cats in Europe: 4 mg/kg PO/SQ q24h x 3 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Tolfenamic Acid need a prescription?

Yes. Tolfenamic Acid is a prescription medication and should only be administered under veterinary supervision.

Educational reference only