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Rocuronium

Prescription

Non-Depolarizing Neuromuscular Blocking Agent

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

1 available

Interactions

1 documented

Formulations

Mechanism of action

Aminosteroid non-depolarizing NMBA that competitively blocks nicotinic acetylcholine receptors at the neuromuscular junction. Fastest onset of non-depolarizing agents (1–2 min). Can be fully reversed by sugammadex (gamma-cyclodextrin — encapsulation reversal).

At a glance

Class

Non-Depolarizing Neuromuscular Blocking Agent

Schedule

Prescription

Storage

Refrigerate 2–8°C; stable 60 days at room temperature

Dosing

🐕

Dog

Fastest onset non-depolarizing NMBA — alternative to succinylcholine for rapid s

Dose

0.3–0.6 mg/kg

Route

Frequency

Boluses q15–30 min or CRI

🐈

Cat

Same indications as dogs

Dose

0.3–0.6 mg/kg

Route

Frequency

Single dose or maintenance boluses

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Refrigerate 2–8°C; stable 60 days at room temperature

Safety

Monitoring parameters

Train-of-four (TOF) neuromuscular monitoringSpO2 and ETCO2Ventilation (mandatory)Adequate reversal before extubation (TOF ratio >0.9)

Educational reference only

Interactions

Moderate — 1

Gentamicin (Systemic)

moderate

Aminoglycosides potentiate non-depolarizing neuromuscular blockade by inhibiting presynaptic ACh release and postsynaptic receptor sensitivity.

Management: If aminoglycoside given perioperatively, reduce NMBA dose and monitor TOF closely. Reversal with neostigmine may be less effective.

Educational reference only

Brands

Other markets

Zemuron

FAQs

Frequently asked questions

›What is Rocuronium?

Rocuronium is a non-depolarizing neuromuscular blocking agent used in pets. Aminosteroid non-depolarizing NMBA that competitively blocks nicotinic acetylcholine receptors at the neuromuscular junction. Fastest onset of non-depolarizing agents (1–2 min). Can be fully reversed by sugammadex (gamma-cyclodextrin — encapsulation reversal).

›What is Rocuronium used for in pets?

Rocuronium is used in veterinary medicine for: Fastest onset non-depolarizing NMBA — alternative to succinylcholine for rapid s; Same indications as dogs.

›What is the Rocuronium dose for dogs?

For dogs, Rocuronium is typically dosed as follows — Fastest onset non-depolarizing NMBA — alternative to succinylcholine for rapid s: 0.3–0.6 mg/kg IV Boluses q15–30 min or CRI. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Rocuronium dose for cats?

For cats, Rocuronium is typically dosed as follows — Same indications as dogs: 0.3–0.6 mg/kg IV Single dose or maintenance boluses. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Rocuronium need a prescription?

Yes. Rocuronium is a prescription medication and should only be administered under veterinary supervision.

Educational reference only