Irreversibly inhibits H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of gastric acid secretion. Effective regardless of stimulation pathway. More rapid onset than other PPIs.
At a glance
Class
Proton Pump Inhibitor (PPI)
Storage
Store at room temperature below 25°C, protect from moisture and light
Dosing
Acid suppression for gastric ulceration, esophagitis, GERD, and Helicobacter tre
Used for esophagitis, gastric ulceration, and hyperacidity
Safety
Clinical response (GI symptom resolution)Electrolytes with prolonged useEndoscopy for refractory cases
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Rabeprazole?
Rabeprazole is a proton pump inhibitor (ppi) used in pets. Irreversibly inhibits H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of gastric acid secretion. Effective regardless of stimulation pathway. More rapid onset than other PPIs.
›What is Rabeprazole used for in pets?
Rabeprazole is used in veterinary medicine for: Acid suppression for gastric ulceration, esophagitis, GERD, and Helicobacter tre; Used for esophagitis, gastric ulceration, and hyperacidity.
›What is the Rabeprazole dose for dogs?
For dogs, Rabeprazole is typically dosed as follows — Acid suppression for gastric ulceration, esophagitis, GERD, and Helicobacter tre: 1–2 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Rabeprazole dose for cats?
For cats, Rabeprazole is typically dosed as follows — Used for esophagitis, gastric ulceration, and hyperacidity: 1–2 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Rabeprazole need a prescription?
Yes. Rabeprazole is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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