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Pantoprazole

Prescription
Proton pump inhibitor (PPI)
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Interactions
1 documented
Formulations
3

Mechanism of action

Irreversibly inhibits H+/K+ ATPase in gastric parietal cells; preferred for IV administration due to better compatibility with IV fluids than omeprazole

At a glance

Class
Proton pump inhibitor (PPI)
Schedule
Prescription
Storage
Store below 25°C; reconstituted IV solution use within 6h

Dosing

🐕

Dog

Gastric ulceration / GI bleeding / Critical care acid suppression
Dose
0.7–1 mg/kg
Route
IV, PO
Frequency
SID to BID
Max dose
40 mg/dose; 80 mg/day
Duration: As clinically indicated; IV for critical care, transition to PO
🐈

Cat

Gastric ulceration / GI bleeding
Dose
0.5–1 mg/kg
Route
IV, PO
Frequency
SID to BID
Max dose
10 mg/dose; 20 mg/day
Duration: As clinically indicated

Formulations

💊

Tablet (enteric coated) — 2

Strength
20mg
Available in India
Strength
40mg
Available in India
💉

Powder for injection — 1

Strength
40mg vial
Available in India

Storage

Store below 25°C; reconstituted IV solution use within 6h

Safety

Absolute contraindications — do not use

  • Known hypersensitivity to PPIs

Adverse effects

Common
Mild GI upset
Serious
Hypomagnesemia (prolonged use)

Monitoring parameters

GI signsMagnesium (prolonged use)

Interactions

Moderate — 1

Ketoconazole
moderate
PPIs raise gastric pH, reducing ketoconazole absorption which requires acidic environment
Management: Separate administration by 2 hours. Give ketoconazole with acidic food/drink. Consider itraconazole instead.

Brands

International

Protonix
Pfizer

India

Pantodac
Zydus Cadila
Pan-D
Alkem

FAQs

Frequently asked questions

›What is Pantoprazole?
Pantoprazole is a proton pump inhibitor (ppi) used in pets. Irreversibly inhibits H+/K+ ATPase in gastric parietal cells; preferred for IV administration due to better compatibility with IV fluids than omeprazole
›What is Pantoprazole used for in pets?
Pantoprazole is used in veterinary medicine for: Gastric ulceration / GI bleeding / Critical care acid suppression; Gastric ulceration / GI bleeding.
›What is the Pantoprazole dose for dogs?
For dogs, Pantoprazole is typically dosed as follows — Gastric ulceration / GI bleeding / Critical care acid suppression: 0.7–1 mg/kg IV/PO SID to BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Pantoprazole dose for cats?
For cats, Pantoprazole is typically dosed as follows — Gastric ulceration / GI bleeding: 0.5–1 mg/kg IV/PO SID to BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Pantoprazole?
Common: Mild GI upset. Serious (call your vet immediately): Hypomagnesemia (prolonged use).
›Does Pantoprazole need a prescription?
Yes. Pantoprazole is a prescription medication and should only be administered under veterinary supervision.
›When should Pantoprazole not be used?
Do not use Pantoprazole if: Known hypersensitivity to PPIs.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Related medicines

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Esomeprazole
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Irreversibly inhibits the H+/K+ ATPase proton pump in gastric parietal cells, profoundly suppressing gastric acid secretion
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Omeprazole
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Irreversibly inhibits the H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion
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Rabeprazole
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Irreversibly inhibits H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of gastric acid secretion. Effective regardless of stimulation pathway. More rapid onset than other PPIs.
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