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Pantoprazole

Prescription
Proton pump inhibitor (PPI)
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Interactions
1 documented
Formulations
3

Mechanism of action

Irreversibly inhibits H+/K+ ATPase in gastric parietal cells; preferred for IV administration due to better compatibility with IV fluids than omeprazole

At a glance

Class
Proton pump inhibitor (PPI)
Schedule
Prescription
Storage
Store below 25°C; reconstituted IV solution use within 6h

Dosing

🐕

Dog

Gastric ulceration / GI bleeding / Critical care acid suppression
Dose
0.7–1 mg/kg
Route
IV, PO
Frequency
SID to BID
Max dose
40 mg/dose; 80 mg/day
Duration: As clinically indicated; IV for critical care, transition to PO
🐈

Cat

Gastric ulceration / GI bleeding
Dose
0.5–1 mg/kg
Route
IV, PO
Frequency
SID to BID
Max dose
10 mg/dose; 20 mg/day
Duration: As clinically indicated
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Tablet (enteric coated) — 2

Strength
20mg
Available in India
Strength
40mg
Available in India
💉

Powder for injection — 1

Strength
40mg vial
Available in India

Storage

Store below 25°C; reconstituted IV solution use within 6h

Safety

Absolute contraindications — do not use

  • Known hypersensitivity to PPIs

Adverse effects

Common
Mild GI upset
Serious
Hypomagnesemia (prolonged use)

Monitoring parameters

GI signsMagnesium (prolonged use)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

Moderate — 1

Ketoconazole
moderate
PPIs raise gastric pH, reducing ketoconazole absorption which requires acidic environment
Management: Separate administration by 2 hours. Give ketoconazole with acidic food/drink. Consider itraconazole instead.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Brands

International

Protonix
Pfizer

India

Pantodac
Zydus Cadila
Pan-D
Alkem

FAQs

Frequently asked questions

›What is Pantoprazole?
Pantoprazole is a proton pump inhibitor (ppi) used in pets. Irreversibly inhibits H+/K+ ATPase in gastric parietal cells; preferred for IV administration due to better compatibility with IV fluids than omeprazole
›What is Pantoprazole used for in pets?
Pantoprazole is used in veterinary medicine for: Gastric ulceration / GI bleeding / Critical care acid suppression; Gastric ulceration / GI bleeding.
›What is the Pantoprazole dose for dogs?
For dogs, Pantoprazole is typically dosed as follows — Gastric ulceration / GI bleeding / Critical care acid suppression: 0.7–1 mg/kg IV/PO SID to BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Pantoprazole dose for cats?
For cats, Pantoprazole is typically dosed as follows — Gastric ulceration / GI bleeding: 0.5–1 mg/kg IV/PO SID to BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Pantoprazole?
Common: Mild GI upset. Serious (call your vet immediately): Hypomagnesemia (prolonged use).
›Does Pantoprazole need a prescription?
Yes. Pantoprazole is a prescription medication and should only be administered under veterinary supervision.
›When should Pantoprazole not be used?
Do not use Pantoprazole if: Known hypersensitivity to PPIs.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Proton pump inhibitor).

Esomeprazole
Rx
Irreversibly inhibits the H+/K+ ATPase proton pump in gastric parietal cells, profoundly suppressing gastric acid secretion
dogcat
Omeprazole
Rx
Irreversibly inhibits the H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion
dogcat
Rabeprazole
Rx
Irreversibly inhibits H+/K+-ATPase (proton pump) in gastric parietal cells, blocking the final step of gastric acid secretion. Effective regardless of stimulation pathway. More rapid onset than other PPIs.
dogcat
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