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Proparacaine Ophthalmic

Prescription
Ophthalmic Topical Anesthetic
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
1

Mechanism of action

Ester-type local anesthetic that blocks voltage-gated sodium channels in corneal sensory nerve endings, providing rapid topical anesthesia of the corneal and conjunctival surface within 30 seconds. Duration 15–20 minutes.

At a glance

Class
Ophthalmic Topical Anesthetic
Schedule
Prescription
Storage
Refrigerate (optimal) or room temperature; discard if discolored

Dosing

🐕

Dog

Used for IOP measurement (tonometry), corneal/conjunctival procedures, foreign b
Dose
Route
Ophthalmic
Frequency
Single application; repeat for procedures
🐈

Cat

Same as dogs
Dose
Route
Ophthalmic
Frequency
Single application

Formulations

💊

Other — 1

Strength

Storage

Refrigerate (optimal) or room temperature; discard if discolored

Safety

Monitoring parameters

In-office use only — no monitoring needed for single applicationIf accidental chronic exposure: fluorescein staining, corneal thickness

Interactions

No documented interactions.

Brands

Other markets

Alcaine
Alcon
Ophthaine

FAQs

Frequently asked questions

What is Proparacaine Ophthalmic?
Proparacaine Ophthalmic is a ophthalmic topical anesthetic used in pets. Ester-type local anesthetic that blocks voltage-gated sodium channels in corneal sensory nerve endings, providing rapid topical anesthesia of the corneal and conjunctival surface within 30 seconds. Duration 15–20 minutes.
What is Proparacaine Ophthalmic used for in pets?
Proparacaine Ophthalmic is used in veterinary medicine for: Used for IOP measurement (tonometry), corneal/conjunctival procedures, foreign b; Same as dogs.
What is the Proparacaine Ophthalmic dose for dogs?
For dogs, Proparacaine Ophthalmic is typically dosed as follows — Used for IOP measurement (tonometry), corneal/conjunctival procedures, foreign b: undefined undefined Ophthalmic Single application; repeat for procedures. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Proparacaine Ophthalmic dose for cats?
For cats, Proparacaine Ophthalmic is typically dosed as follows — Same as dogs: undefined undefined Ophthalmic Single application. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Proparacaine Ophthalmic need a prescription?
Yes. Proparacaine Ophthalmic is a prescription medication and should only be administered under veterinary supervision.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Related medicines

Other medicines in the same class (Ophthalmic Topical Anesthetic).

Tetracaine Ophthalmic
Rx
Ester-type local anesthetic with slightly slower onset (60 sec) but longer duration (15–25 min) than proparacaine. More irritating on application but provides deeper anesthesia — preferred for some procedures.
dogcat