Prodrug that penetrates the cornea intact and is converted to active amfenac by intraocular hydrolases. Amfenac inhibits COX-1 and COX-2 within the eye. Prodrug design provides better corneal penetration and less surface toxicity than other ophthalmic NSAIDs.
At a glance
Class
Ophthalmic NSAID (Prodrug)
Storage
Store at room temperature; shake before use
Dosing
Used for post-surgical inflammation (cataract surgery), anterior uveitis adjunct
Frequency
q8–24h depending on formulation
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Corneal integrity (fluorescein before prescribing)Inflammation responseIOP
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
Brands
Other markets
Ilevro (0.3%)
Novartis/Alcon
FAQs
Frequently asked questions
›What is Nepafenac Ophthalmic?
Nepafenac Ophthalmic is a ophthalmic nsaid (prodrug) used in pets. Prodrug that penetrates the cornea intact and is converted to active amfenac by intraocular hydrolases. Amfenac inhibits COX-1 and COX-2 within the eye. Prodrug design provides better corneal penetration and less surface toxicity than other ophthalmic NSAIDs.
›What is Nepafenac Ophthalmic used for in pets?
Nepafenac Ophthalmic is used in veterinary medicine for: Used for post-surgical inflammation (cataract surgery), anterior uveitis adjunct; Same indications.
›What is the Nepafenac Ophthalmic dose for dogs?
For dogs, Nepafenac Ophthalmic is typically dosed as follows — Used for post-surgical inflammation (cataract surgery), anterior uveitis adjunct: undefined undefined Ophthalmic q8–24h depending on formulation. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Nepafenac Ophthalmic dose for cats?
For cats, Nepafenac Ophthalmic is typically dosed as follows — Same indications: undefined undefined Ophthalmic q8–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Nepafenac Ophthalmic need a prescription?
Yes. Nepafenac Ophthalmic is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database