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Metamizole (Dipyrone)

PrescriptionCDSCO approved

Pyrazolone analgesic / Antipyretic / Antispasmodic

Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

3 available

Interactions

1 documented

Formulations

Mechanism of action

Inhibits COX-3 (central) and blocks prostaglandin synthesis; also has direct smooth muscle spasmolytic effects; widely used in Indian veterinary practice

At a glance

Class

Pyrazolone analgesic / Antipyretic / Antispasmodic

Schedule

Prescription

Storage

Store below 25°C, protect from light

CDSCO (India)

Vet-approved — 1970-01

Dosing

🐕

Dog

Pain / Fever / Visceral colic (antispasmodic)

Dose

20–35 mg/kg

Route

PO, IV (slow), IM, SC

Frequency

BID to TID

Max dose

1500 mg/dose; 4500 mg/day

Duration: Short-term (3–5 days); do not use long-term

🐈

Cat

Fever / Acute pain

Dose

20–25 mg/kg

Route

IV (slow), IM, SC

Frequency

BID

Max dose

250 mg/dose; 500 mg/day

Duration: Short-term only (1–3 days); avoid PO in cats if possible

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Tablet — 1

Strength

500mg

Available in India

💉

Injection — 1

Strength

500mg/mL

Available in India

Storage

Store below 25°C, protect from light

Safety

Absolute contraindications — do not use

Known hypersensitivity to pyrazolones

Use with caution

Pre-existing bone marrow suppression
Risk of agranulocytosis
Cats (use cautiously, short-term only)
Limited safety data in cats

Adverse effects

Common

Mild GI upset

Hypotension (IV too rapid)

Serious

Agranulocytosis (rare)

Aplastic anemia (rare)

Anaphylaxis

Monitoring parameters

Temperature (antipyretic response)CBC (if prolonged use)Blood pressure (IV)

Educational reference only

Interactions

Major — 1

Methotrexate

major

Metamizole may reduce renal clearance of methotrexate and both cause bone marrow suppression

Management: Avoid concurrent use during methotrexate therapy. Use opioids for analgesia.

Educational reference only

Brands

International

Novalgin

Sanofi

India

Analgin Vet

Intas

Novalgin

Sanofi India

FAQs

Frequently asked questions

›What is Metamizole (Dipyrone)?

Metamizole (Dipyrone) is a pyrazolone analgesic / antipyretic / antispasmodic used in pets. Inhibits COX-3 (central) and blocks prostaglandin synthesis; also has direct smooth muscle spasmolytic effects; widely used in Indian veterinary practice

›What is Metamizole (Dipyrone) used for in pets?

Metamizole (Dipyrone) is used in veterinary medicine for: Pain / Fever / Visceral colic (antispasmodic); Fever / Acute pain.

›What is the Metamizole (Dipyrone) dose for dogs?

For dogs, Metamizole (Dipyrone) is typically dosed as follows — Pain / Fever / Visceral colic (antispasmodic): 20–35 mg/kg PO/IV (slow)/IM/SC BID to TID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Metamizole (Dipyrone) dose for cats?

For cats, Metamizole (Dipyrone) is typically dosed as follows — Fever / Acute pain: 20–25 mg/kg IV (slow)/IM/SC BID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What are the side effects of Metamizole (Dipyrone)?

Common: Mild GI upset, Hypotension (IV too rapid). Serious (call your vet immediately): Agranulocytosis (rare), Aplastic anemia (rare), Anaphylaxis.

›Does Metamizole (Dipyrone) need a prescription?

Yes. Metamizole (Dipyrone) is a prescription medication and should only be administered under veterinary supervision.

›When should Metamizole (Dipyrone) not be used?

Do not use Metamizole (Dipyrone) if: Known hypersensitivity to pyrazolones.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Pyrazolone analgesic / Antipyretic / Antispasmodic).

Dipyrone (Metamizole)

Prodrug hydrolyzed to active metabolites (4-methylaminoantipyrine, 4-aminoantipyrine) that inhibit COX-1 and COX-2 centrally and peripherally, reduce prostaglandin synthesis, and have antispasmodic effects on smooth muscle. Potent antipyretic.

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