Prodrug hydrolyzed to active metabolites (4-methylaminoantipyrine, 4-aminoantipyrine) that inhibit COX-1 and COX-2 centrally and peripherally, reduce prostaglandin synthesis, and have antispasmodic effects on smooth muscle. Potent antipyretic.
At a glance
Class
Pyrazolone Analgesic / Antipyretic / Antispasmodic
Storage
Store at room temperature, protect from light
Dosing
Excellent antipyretic and analgesic
Lower frequency in cats due to slower metabolism
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Temperature responseCBC with prolonged useBlood pressure (IV administration)Pain scores
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Dipyrone (Metamizole)?
Dipyrone (Metamizole) is a pyrazolone analgesic / antipyretic / antispasmodic used in pets. Prodrug hydrolyzed to active metabolites (4-methylaminoantipyrine, 4-aminoantipyrine) that inhibit COX-1 and COX-2 centrally and peripherally, reduce prostaglandin synthesis, and have antispasmodic effects on smooth muscle. Potent antipyretic.
›What is Dipyrone (Metamizole) used for in pets?
Dipyrone (Metamizole) is used in veterinary medicine for: Excellent antipyretic and analgesic; Lower frequency in cats due to slower metabolism.
›What is the Dipyrone (Metamizole) dose for dogs?
For dogs, Dipyrone (Metamizole) is typically dosed as follows — Excellent antipyretic and analgesic: 25–50 mg/kg IV/IM/SQ/PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Dipyrone (Metamizole) dose for cats?
For cats, Dipyrone (Metamizole) is typically dosed as follows — Lower frequency in cats due to slower metabolism: 25 mg/kg IV/SQ q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Dipyrone (Metamizole) need a prescription?
Yes. Dipyrone (Metamizole) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database