Prodrug hydrolyzed to active metabolites (4-methylaminoantipyrine, 4-aminoantipyrine) that inhibit COX-1 and COX-2 centrally and peripherally, reduce prostaglandin synthesis, and have antispasmodic effects on smooth muscle. Potent antipyretic.
At a glance
Class
Pyrazolone Analgesic / Antipyretic / Antispasmodic
Storage
Store at room temperature, protect from light
Dosing
Excellent antipyretic and analgesic
Lower frequency in cats due to slower metabolism
Safety
Temperature responseCBC with prolonged useBlood pressure (IV administration)Pain scores
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Dipyrone (Metamizole)?
Dipyrone (Metamizole) is a pyrazolone analgesic / antipyretic / antispasmodic used in pets. Prodrug hydrolyzed to active metabolites (4-methylaminoantipyrine, 4-aminoantipyrine) that inhibit COX-1 and COX-2 centrally and peripherally, reduce prostaglandin synthesis, and have antispasmodic effects on smooth muscle. Potent antipyretic.
›What is Dipyrone (Metamizole) used for in pets?
Dipyrone (Metamizole) is used in veterinary medicine for: Excellent antipyretic and analgesic; Lower frequency in cats due to slower metabolism.
›What is the Dipyrone (Metamizole) dose for dogs?
For dogs, Dipyrone (Metamizole) is typically dosed as follows — Excellent antipyretic and analgesic: 25–50 mg/kg IV/IM/SQ/PO q8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Dipyrone (Metamizole) dose for cats?
For cats, Dipyrone (Metamizole) is typically dosed as follows — Lower frequency in cats due to slower metabolism: 25 mg/kg IV/SQ q12–24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Dipyrone (Metamizole) need a prescription?
Yes. Dipyrone (Metamizole) is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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