Synthetic progestogen that binds progesterone receptors, suppressing gonadotropin release (LH and FSH) and inhibiting estrus. Also has anti-inflammatory and immunomodulatory properties. Long-acting depot formulation provides sustained progestogenic effect.
At a glance
Class
Synthetic Progestogen
Storage
Store at room temperature; shake injectable suspension well before use
Dosing
Used for estrus suppression, testosterone-responsive conditions, and some dermat
Frequency
Variable — see notes
Used for eosinophilic granuloma complex, miliary dermatitis, and estrus suppress
Safety
Blood glucoseUterine health (ultrasound)Mammary gland examinationBody weightAdrenal function
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Medroxyprogesterone Acetate?
Medroxyprogesterone Acetate is a synthetic progestogen used in pets. Synthetic progestogen that binds progesterone receptors, suppressing gonadotropin release (LH and FSH) and inhibiting estrus. Also has anti-inflammatory and immunomodulatory properties. Long-acting depot formulation provides sustained progestogenic effect.
›What is Medroxyprogesterone Acetate used for in pets?
Medroxyprogesterone Acetate is used in veterinary medicine for: Used for estrus suppression, testosterone-responsive conditions, and some dermat; Used for eosinophilic granuloma complex, miliary dermatitis, and estrus suppress.
›What is the Medroxyprogesterone Acetate dose for dogs?
For dogs, Medroxyprogesterone Acetate is typically dosed as follows — Used for estrus suppression, testosterone-responsive conditions, and some dermat: 2–5 mg/kg IM/SQ/PO Variable — see notes. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Medroxyprogesterone Acetate dose for cats?
For cats, Medroxyprogesterone Acetate is typically dosed as follows — Used for eosinophilic granuloma complex, miliary dermatitis, and estrus suppress: 2.5–5 mg/kg IM/SQ/PO Variable. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Medroxyprogesterone Acetate need a prescription?
Yes. Medroxyprogesterone Acetate is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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