First alkylating agent developed (WWII mustard gas derivative). Bifunctional alkylator forming interstrand DNA crosslinks. Component of MOPP rescue protocol for lymphoma. Extremely vesicant. Cell-cycle non-specific.
At a glance
Class
Nitrogen Mustard Alkylating Agent (Chemotherapy)
Schedule
Prescription (Chemotherapy)
Storage
Store at room temperature; reconstituted unstable — use within minutes; chemotherapy precautions
Dosing
Rescue protocol for relapsed lymphoma
Frequency
Day 1 of each MOPP cycle (q4 weeks)
Rarely used in feline oncology
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
CBC at nadirCatheter patency (confirm blood return before/during injection)GI toleranceTumor response
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Mechlorethamine?
Mechlorethamine is a nitrogen mustard alkylating agent (chemotherapy) used in pets. First alkylating agent developed (WWII mustard gas derivative). Bifunctional alkylator forming interstrand DNA crosslinks. Component of MOPP rescue protocol for lymphoma. Extremely vesicant. Cell-cycle non-specific.
›What is Mechlorethamine used for in pets?
Mechlorethamine is used in veterinary medicine for: Rescue protocol for relapsed lymphoma; Rarely used in feline oncology.
›What is the Mechlorethamine dose for dogs?
For dogs, Mechlorethamine is typically dosed as follows — Rescue protocol for relapsed lymphoma: undefined undefined PO Day 1 of each MOPP cycle (q4 weeks). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Mechlorethamine dose for cats?
For cats, Mechlorethamine is typically dosed as follows — Rarely used in feline oncology: undefined undefined IV Per protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Mechlorethamine need a prescription?
Yes. Mechlorethamine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database