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Ifosfamide

Prescription

Nitrogen Mustard Alkylating Agent (Chemotherapy)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

1 available

Interactions

1 documented

Formulations

Mechanism of action

Oxazaphosphorine prodrug activated by hepatic CYP3A4 to isophosphoramide mustard and acrolein. Alkylates DNA causing crosslinks and strand breaks. Cell-cycle non-specific. Requires mesna co-administration to prevent hemorrhagic cystitis.

At a glance

Class

Nitrogen Mustard Alkylating Agent (Chemotherapy)

Schedule

Prescription (Chemotherapy)

Storage

Store at room temperature; reconstituted stable 24h at room temperature; chemotherapy precautions

Dosing

🐕

Dog

Used for soft tissue sarcomas, osteosarcoma, hemangiosarcoma, and transitional c

Dose

350–375 mg/m²

Route

Frequency

q3 weeks

🐈

Cat

Very limited feline data

Dose

—

Route

Frequency

Per protocol

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Store at room temperature; reconstituted stable 24h at room temperature; chemotherapy precautions

Safety

Monitoring parameters

CBC at nadirUrinalysis (hematuria — cystitis)Renal functionNeurological status (encephalopathy)Mesna compliance

Educational reference only

Interactions

Major — 1

Meloxicam

major

Both are potentially nephrotoxic. NSAID reduces renal prostaglandin-mediated blood flow + ifosfamide has direct tubular toxicity.

Management: Avoid NSAIDs during ifosfamide cycles. Use opioids for pain management.

Educational reference only

Brands

Other markets

Ifex

FAQs

Frequently asked questions

›What is Ifosfamide?

Ifosfamide is a nitrogen mustard alkylating agent (chemotherapy) used in pets. Oxazaphosphorine prodrug activated by hepatic CYP3A4 to isophosphoramide mustard and acrolein. Alkylates DNA causing crosslinks and strand breaks. Cell-cycle non-specific. Requires mesna co-administration to prevent hemorrhagic cystitis.

›What is Ifosfamide used for in pets?

Ifosfamide is used in veterinary medicine for: Used for soft tissue sarcomas, osteosarcoma, hemangiosarcoma, and transitional c; Very limited feline data.

›What is the Ifosfamide dose for dogs?

For dogs, Ifosfamide is typically dosed as follows — Used for soft tissue sarcomas, osteosarcoma, hemangiosarcoma, and transitional c: 350–375 mg/m² IV q3 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Ifosfamide dose for cats?

For cats, Ifosfamide is typically dosed as follows — Very limited feline data: undefined undefined IV Per protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Ifosfamide need a prescription?

Yes. Ifosfamide is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Nitrogen Mustard Alkylating Agent).

Mechlorethamine

First alkylating agent developed (WWII mustard gas derivative). Bifunctional alkylator forming interstrand DNA crosslinks. Component of MOPP rescue protocol for lymphoma. Extremely vesicant. Cell-cycle non-specific.

dogcat