Selectively blocks 5-HT3 serotonin receptors in the CTZ and vagal afferents, preventing serotonin-induced nausea and vomiting. More selective and longer-acting than ondansetron.
At a glance
Class
5-HT3 Serotonin Receptor Antagonist / Antiemetic
Storage
Store at room temperature, protect from light
Dosing
Used for chemotherapy-induced nausea
Frequency
Once per cycle; patch lasts 5–7 days
Limited feline data
Frequency
Once pre-chemotherapy
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Emesis controlCardiac rhythmElectrolytes
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Granisetron?
Granisetron is a 5-ht3 serotonin receptor antagonist / antiemetic used in pets. Selectively blocks 5-HT3 serotonin receptors in the CTZ and vagal afferents, preventing serotonin-induced nausea and vomiting. More selective and longer-acting than ondansetron.
›What is Granisetron used for in pets?
Granisetron is used in veterinary medicine for: Used for chemotherapy-induced nausea; Limited feline data.
›What is the Granisetron dose for dogs?
For dogs, Granisetron is typically dosed as follows — Used for chemotherapy-induced nausea: 0.1 mg/kg IV/Transdermal Once per cycle; patch lasts 5–7 days. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Granisetron dose for cats?
For cats, Granisetron is typically dosed as follows — Limited feline data: 0.1 mg/kg IV Once pre-chemotherapy. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Granisetron need a prescription?
Yes. Granisetron is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database