Selectively antagonizes 5-HT3 serotonin receptors in the chemoreceptor trigger zone (CTZ) and peripheral vagal nerve terminals in the GI tract, preventing serotonin-induced nausea and vomiting.
At a glance
Class
5-HT3 Serotonin Receptor Antagonist / Antiemetic
Storage
Store at room temperature; diluted IV solution stable 24h at room temperature
Dosing
Used to prevent vomiting from chemotherapy, motion sickness, and parvovirus
Effective antiemetic in cats
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Cardiac rhythm (especially with IV use or cardiac disease)Electrolytes (K, Mg) before administration
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Dolasetron?
Dolasetron is a 5-ht3 serotonin receptor antagonist / antiemetic used in pets. Selectively antagonizes 5-HT3 serotonin receptors in the chemoreceptor trigger zone (CTZ) and peripheral vagal nerve terminals in the GI tract, preventing serotonin-induced nausea and vomiting.
›What is Dolasetron used for in pets?
Dolasetron is used in veterinary medicine for: Used to prevent vomiting from chemotherapy, motion sickness, and parvovirus; Effective antiemetic in cats.
›What is the Dolasetron dose for dogs?
For dogs, Dolasetron is typically dosed as follows — Used to prevent vomiting from chemotherapy, motion sickness, and parvovirus: 0.6 mg/kg PO/IV q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Dolasetron dose for cats?
For cats, Dolasetron is typically dosed as follows — Effective antiemetic in cats: 0.6 mg/kg PO/IV q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Dolasetron need a prescription?
Yes. Dolasetron is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database