Activates peroxisome proliferator-activated receptor alpha (PPARα), upregulating lipoprotein lipase and reducing apolipoprotein C-III, leading to increased triglyceride clearance and reduced VLDL production. Also modestly raises HDL and lowers LDL.
At a glance
Class
Fibric Acid Derivative (Lipid-Lowering Agent)
Storage
Store at room temperature below 30°C, protect from moisture
Dosing
Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia
Feline hyperlipidemia is uncommon
Safety
Fasting triglycerides and cholesterol at 4–6 weeks then q3–6 monthsHepatic enzymesCreatinine (may elevate without renal damage)
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Fenofibrate?
Fenofibrate is a fibric acid derivative (lipid-lowering agent) used in pets. Activates peroxisome proliferator-activated receptor alpha (PPARα), upregulating lipoprotein lipase and reducing apolipoprotein C-III, leading to increased triglyceride clearance and reduced VLDL production. Also modestly raises HDL and lowers LDL.
›What is Fenofibrate used for in pets?
Fenofibrate is used in veterinary medicine for: Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia; Feline hyperlipidemia is uncommon.
›What is the Fenofibrate dose for dogs?
For dogs, Fenofibrate is typically dosed as follows — Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia: 5–10 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Fenofibrate dose for cats?
For cats, Fenofibrate is typically dosed as follows — Feline hyperlipidemia is uncommon: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Fenofibrate need a prescription?
Yes. Fenofibrate is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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