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Fenofibrate

Prescription
Fibric Acid Derivative (Lipid-Lowering Agent)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
2

Mechanism of action

Activates peroxisome proliferator-activated receptor alpha (PPARα), upregulating lipoprotein lipase and reducing apolipoprotein C-III, leading to increased triglyceride clearance and reduced VLDL production. Also modestly raises HDL and lowers LDL.

At a glance

Class
Fibric Acid Derivative (Lipid-Lowering Agent)
Schedule
Prescription
Storage
Store at room temperature below 30°C, protect from moisture

Dosing

🐕

Dog

Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia
Dose
5–10 mg/kg
Route
PO
Frequency
q24h
🐈

Cat

Feline hyperlipidemia is uncommon
Dose
Route
N, A
Frequency
N/A
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature below 30°C, protect from moisture

Safety

Monitoring parameters

Fasting triglycerides and cholesterol at 4–6 weeks then q3–6 monthsHepatic enzymesCreatinine (may elevate without renal damage)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Tricor
Fenoglide

FAQs

Frequently asked questions

What is Fenofibrate?
Fenofibrate is a fibric acid derivative (lipid-lowering agent) used in pets. Activates peroxisome proliferator-activated receptor alpha (PPARα), upregulating lipoprotein lipase and reducing apolipoprotein C-III, leading to increased triglyceride clearance and reduced VLDL production. Also modestly raises HDL and lowers LDL.
What is Fenofibrate used for in pets?
Fenofibrate is used in veterinary medicine for: Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia; Feline hyperlipidemia is uncommon.
What is the Fenofibrate dose for dogs?
For dogs, Fenofibrate is typically dosed as follows — Used for primary hyperlipidemia (Miniature Schnauzers), secondary hyperlipidemia: 5–10 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Fenofibrate dose for cats?
For cats, Fenofibrate is typically dosed as follows — Feline hyperlipidemia is uncommon: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Fenofibrate need a prescription?
Yes. Fenofibrate is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Fibric Acid Derivative).

Gemfibrozil
Rx
Activates PPARα, increasing lipoprotein lipase activity and reducing hepatic VLDL production. Primarily lowers triglycerides (40–60%) with modest LDL reduction and HDL increase. Older fibrate — fenofibrate generally preferred.
dogcat
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