Competitive H1-receptor antagonist that blocks histamine-mediated vasodilation, increased vascular permeability, and pruritus. Moderate anticholinergic and sedative properties.
At a glance
Class
First-Generation Antihistamine (H1 Blocker)
Storage
Store at room temperature, protect from moisture
Dosing
Used for allergic dermatitis, urticaria, and pruritus
Used for feline allergic skin disease
Safety
Pruritus responseSedation level
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Clemastine?
Clemastine is a first-generation antihistamine (h1 blocker) used in pets. Competitive H1-receptor antagonist that blocks histamine-mediated vasodilation, increased vascular permeability, and pruritus. Moderate anticholinergic and sedative properties.
›What is Clemastine used for in pets?
Clemastine is used in veterinary medicine for: Used for allergic dermatitis, urticaria, and pruritus; Used for feline allergic skin disease.
›What is the Clemastine dose for dogs?
For dogs, Clemastine is typically dosed as follows — Used for allergic dermatitis, urticaria, and pruritus: 0.05–0.1 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Clemastine dose for cats?
For cats, Clemastine is typically dosed as follows — Used for feline allergic skin disease: 0.34–0.68 mg/cat PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Clemastine need a prescription?
Clemastine is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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