Most potent bisphosphonate available. Nitrogen-containing imidazole bisphosphonate that inhibits farnesyl pyrophosphate synthase in osteoclasts >10,000x more potently than first-gen bisphosphonates. Single IV infusion provides months of bone resorption inhibition.
At a glance
Class
Third-Generation Bisphosphonate
Storage
Store at room temperature; diluted solution stable 24h refrigerated
Dosing
Used for hypercalcemia of malignancy (most potent IV bisphosphonate), osteolytic
Used for idiopathic hypercalcemia and hypercalcemia of malignancy
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Renal function (BUN, creatinine) at 48h and 7 days post-infusionSerum ionized calcium at 24h, 48h, 7 daysClinical pain responseHydration status pre-infusion
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Zoledronate (Zoledronic Acid)?
Zoledronate (Zoledronic Acid) is a third-generation bisphosphonate used in pets. Most potent bisphosphonate available. Nitrogen-containing imidazole bisphosphonate that inhibits farnesyl pyrophosphate synthase in osteoclasts >10,000x more potently than first-gen bisphosphonates. Single IV infusion provides months of bone resorption inhibition.
›What is Zoledronate (Zoledronic Acid) used for in pets?
Zoledronate (Zoledronic Acid) is used in veterinary medicine for: Used for hypercalcemia of malignancy (most potent IV bisphosphonate), osteolytic; Used for idiopathic hypercalcemia and hypercalcemia of malignancy.
›What is the Zoledronate (Zoledronic Acid) dose for dogs?
For dogs, Zoledronate (Zoledronic Acid) is typically dosed as follows — Used for hypercalcemia of malignancy (most potent IV bisphosphonate), osteolytic: 0.1–0.25 mg/kg IV infusion q4 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Zoledronate (Zoledronic Acid) dose for cats?
For cats, Zoledronate (Zoledronic Acid) is typically dosed as follows — Used for idiopathic hypercalcemia and hypercalcemia of malignancy: 0.1–0.25 mg/kg IV q4 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Zoledronate (Zoledronic Acid) need a prescription?
Yes. Zoledronate (Zoledronic Acid) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database