Competitive alpha-2 adrenergic receptor antagonist derived from Pausinystalia yohimbe bark. Reverses xylazine and other alpha-2 agonist sedation by displacing agonist from receptors. Less selective than atipamezole.
At a glance
Class
Alpha-2 Adrenergic Antagonist (Reversal Agent)
Storage
Store at room temperature, protect from light
Dosing
Reverses xylazine sedation
Frequency
Single reversal dose; may repeat in 15 min if needed
Reverses xylazine
Frequency
Single reversal dose
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Level of arousal within 5–10 minHeart rateBlood pressureTremors/seizures
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Yohimbine?
Yohimbine is a alpha-2 adrenergic antagonist (reversal agent) used in pets. Competitive alpha-2 adrenergic receptor antagonist derived from Pausinystalia yohimbe bark. Reverses xylazine and other alpha-2 agonist sedation by displacing agonist from receptors. Less selective than atipamezole.
›What is Yohimbine used for in pets?
Yohimbine is used in veterinary medicine for: Reverses xylazine sedation; Reverses xylazine.
›What is the Yohimbine dose for dogs?
For dogs, Yohimbine is typically dosed as follows — Reverses xylazine sedation: 0.25–0.5 mg/kg IV/IM Single reversal dose; may repeat in 15 min if needed. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Yohimbine dose for cats?
For cats, Yohimbine is typically dosed as follows — Reverses xylazine: 0.1 mg/kg IV/IM Single reversal dose. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Yohimbine need a prescription?
Yes. Yohimbine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database