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Vitamin A (Retinol)

Fat-Soluble Vitamin
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
3

Mechanism of action

Essential fat-soluble vitamin that binds retinoic acid receptors (RAR/RXR), regulating gene transcription for epithelial differentiation, immune function, vision (retinal component of rhodopsin), and reproduction. Deficiency causes squamous metaplasia and immune dysfunction.

At a glance

Class
Fat-Soluble Vitamin
Schedule
OTC
Storage
Store at room temperature, protect from light

Dosing

🐕

Dog

Rarely needed in dogs on commercial diets
Dose
400–800 IU/kg
Route
PO
Frequency
q24h
🐈

Cat

Cats fed liver-heavy diets can develop hypervitaminosis A (cervical spondylosis,
Dose
Route
PO
Frequency
q24h

Formulations

💊

Other — 3

Strength
Strength
Strength

Storage

Store at room temperature, protect from light

Safety

Monitoring parameters

Serum retinol levels if toxicity suspectedHepatic enzymesRadiographs (skeletal changes in cats with chronic excess)

Interactions

No documented interactions.

Brands

Other markets

Aquasol A

FAQs

Frequently asked questions

What is Vitamin A (Retinol)?
Vitamin A (Retinol) is a fat-soluble vitamin used in pets. Essential fat-soluble vitamin that binds retinoic acid receptors (RAR/RXR), regulating gene transcription for epithelial differentiation, immune function, vision (retinal component of rhodopsin), and reproduction. Deficiency causes squamous metaplasia and immune dysfunction.
What is Vitamin A (Retinol) used for in pets?
Vitamin A (Retinol) is used in veterinary medicine for: Rarely needed in dogs on commercial diets; Cats fed liver-heavy diets can develop hypervitaminosis A (cervical spondylosis,.
What is the Vitamin A (Retinol) dose for dogs?
For dogs, Vitamin A (Retinol) is typically dosed as follows — Rarely needed in dogs on commercial diets: 400–800 IU/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Vitamin A (Retinol) dose for cats?
For cats, Vitamin A (Retinol) is typically dosed as follows — Cats fed liver-heavy diets can develop hypervitaminosis A (cervical spondylosis,: undefined undefined PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Vitamin A (Retinol) need a prescription?
Vitamin A (Retinol) is available over the counter. Even so, you should consult your veterinarian before giving any medication to your pet.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →