Semi-synthetic derivative of vinblastine that binds tubulin and inhibits microtubule assembly, arresting cells in metaphase. Greater selectivity for mitotic microtubules (less neurotoxicity than vincristine). Active against carcinomas and lymphomas.
At a glance
Class
Semi-Synthetic Vinca Alkaloid (Chemotherapy)
Schedule
Prescription (Chemotherapy)
Storage
Refrigerate 2–8°C; protect from light; chemotherapy precautions
Dosing
Used for pulmonary carcinoma, mammary carcinoma, and transitional cell carcinoma
Frequency
Weekly or q2 weeks per protocol
Safety
CBC at nadir and before each dose (ANC ≥1500 to proceed)Catheter patencyHepatic functionTumor response
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Vinorelbine?
Vinorelbine is a semi-synthetic vinca alkaloid (chemotherapy) used in pets. Semi-synthetic derivative of vinblastine that binds tubulin and inhibits microtubule assembly, arresting cells in metaphase. Greater selectivity for mitotic microtubules (less neurotoxicity than vincristine). Active against carcinomas and lymphomas.
›What is Vinorelbine used for in pets?
Vinorelbine is used in veterinary medicine for: Used for pulmonary carcinoma, mammary carcinoma, and transitional cell carcinoma; Very limited feline data.
›What is the Vinorelbine dose for dogs?
For dogs, Vinorelbine is typically dosed as follows — Used for pulmonary carcinoma, mammary carcinoma, and transitional cell carcinoma: 15–18 mg/m² IV (vesicant) Weekly or q2 weeks per protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Vinorelbine dose for cats?
For cats, Vinorelbine is typically dosed as follows — Very limited feline data: undefined undefined IV Per protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Vinorelbine need a prescription?
Yes. Vinorelbine is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →