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Vinblastine

Prescription

Vinca Alkaloid (Chemotherapy)

Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team

Species

Dog, Cat

Brands

1 available

Interactions

1 documented

Formulations

Mechanism of action

Binds tubulin and inhibits microtubule assembly, arresting cells in metaphase (M-phase specific). More myelosuppressive than vincristine but less neurotoxic. Key drug for mast cell tumors.

At a glance

Class

Vinca Alkaloid (Chemotherapy)

Schedule

Prescription (Chemotherapy)

Storage

Refrigerate 2–8°C; protect from light; chemotherapy precautions

Dosing

🐕

Dog

Drug of choice for canine mast cell tumors (combined with prednisone — Thamm pro

Dose

2–3 mg/m²

Route

Frequency

q1–2 weeks per protocol

🐈

Cat

Used for feline mast cell tumors

Dose

2 mg/m²

Route

Frequency

q1–2 weeks

Educational reference only

This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

—

Storage

Refrigerate 2–8°C; protect from light; chemotherapy precautions

Safety

Monitoring parameters

CBC at nadir (day 4–7) and before each doseCatheter patency before injectionTumor responseGI tolerance

Educational reference only

Interactions

Moderate — 1

Ketoconazole (Systemic)

moderate

Ketoconazole inhibits CYP3A4 and P-glycoprotein, potentially increasing vinblastine levels and myelosuppression.

Management: Monitor CBC more closely. Consider dose reduction of vinblastine.

Educational reference only

Brands

Other markets

Velban

FAQs

Frequently asked questions

›What is Vinblastine?

Vinblastine is a vinca alkaloid (chemotherapy) used in pets. Binds tubulin and inhibits microtubule assembly, arresting cells in metaphase (M-phase specific). More myelosuppressive than vincristine but less neurotoxic. Key drug for mast cell tumors.

›What is Vinblastine used for in pets?

Vinblastine is used in veterinary medicine for: Drug of choice for canine mast cell tumors (combined with prednisone — Thamm pro; Used for feline mast cell tumors.

›What is the Vinblastine dose for dogs?

For dogs, Vinblastine is typically dosed as follows — Drug of choice for canine mast cell tumors (combined with prednisone — Thamm pro: 2–3 mg/m² PO q1–2 weeks per protocol. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›What is the Vinblastine dose for cats?

For cats, Vinblastine is typically dosed as follows — Used for feline mast cell tumors: 2 mg/m² IV q1–2 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.

›Does Vinblastine need a prescription?

Yes. Vinblastine is a prescription medication and should only be administered under veterinary supervision.

Educational reference only

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

Plumb's Veterinary Drug Handbook
Withrow & MacEwen's Small Animal Clinical Oncology
Merck Veterinary Manual
NRC Nutrient Requirements of Dogs and Cats
Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

ASPCA Animal Poison Control Center Guidelines
AAHA Diabetes Management Guidelines
ASPCA Poison Control Guidelines
RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

EPIC Study (J Vet Intern Med 2016)
JVIM FAT CAT Study

Regulatory & approvals — 1

CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Vinca Alkaloid).

Vincristine

Binds to tubulin dimers, preventing microtubule polymerization and disrupting mitotic spindle formation, arresting cells in metaphase

dogcat