Selectively inhibits exportin 1 (XPO1/CRM1), the nuclear export protein that transports tumor suppressor proteins (p53, p21, FOXO, IκB) out of the nucleus. Blocking export restores nuclear tumor suppressor function, inducing cancer cell apoptosis while sparing normal cells.
At a glance
Class
Selective Inhibitor of Nuclear Export (SINE) / Antineoplastic
Schedule
Prescription (Chemotherapy)
Storage
Store at room temperature 20–25°C; handle with gloves
Dosing
FDA-conditionally approved for canine lymphoma
Frequency
MWF (3 days/week)
Not approved or studied in cats
Safety
CBC weekly for first month then biweeklyBody weight weeklyAppetite monitoringHepatic and renal functionTumor response
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Verdinexor?
Verdinexor is a selective inhibitor of nuclear export (sine) / antineoplastic used in pets. Selectively inhibits exportin 1 (XPO1/CRM1), the nuclear export protein that transports tumor suppressor proteins (p53, p21, FOXO, IκB) out of the nucleus. Blocking export restores nuclear tumor suppressor function, inducing cancer cell apoptosis while sparing normal cells.
›What is Verdinexor used for in pets?
Verdinexor is used in veterinary medicine for: FDA-conditionally approved for canine lymphoma; Not approved or studied in cats.
›What is the Verdinexor dose for dogs?
For dogs, Verdinexor is typically dosed as follows — FDA-conditionally approved for canine lymphoma: 1.25 mg/kg PO MWF (3 days/week). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Verdinexor dose for cats?
For cats, Verdinexor is typically dosed as follows — Not approved or studied in cats: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Verdinexor need a prescription?
Yes. Verdinexor is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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