Selectively inhibits exportin 1 (XPO1/CRM1), the nuclear export protein that transports tumor suppressor proteins (p53, p21, FOXO, IκB) out of the nucleus. Blocking export restores nuclear tumor suppressor function, inducing cancer cell apoptosis while sparing normal cells.
At a glance
Class
Selective Inhibitor of Nuclear Export (SINE) / Antineoplastic
Schedule
Prescription (Chemotherapy)
Storage
Store at room temperature 20–25°C; handle with gloves
Dosing
FDA-conditionally approved for canine lymphoma
Frequency
MWF (3 days/week)
Not approved or studied in cats
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
CBC weekly for first month then biweeklyBody weight weeklyAppetite monitoringHepatic and renal functionTumor response
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Verdinexor?
Verdinexor is a selective inhibitor of nuclear export (sine) / antineoplastic used in pets. Selectively inhibits exportin 1 (XPO1/CRM1), the nuclear export protein that transports tumor suppressor proteins (p53, p21, FOXO, IκB) out of the nucleus. Blocking export restores nuclear tumor suppressor function, inducing cancer cell apoptosis while sparing normal cells.
›What is Verdinexor used for in pets?
Verdinexor is used in veterinary medicine for: FDA-conditionally approved for canine lymphoma; Not approved or studied in cats.
›What is the Verdinexor dose for dogs?
For dogs, Verdinexor is typically dosed as follows — FDA-conditionally approved for canine lymphoma: 1.25 mg/kg PO MWF (3 days/week). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Verdinexor dose for cats?
For cats, Verdinexor is typically dosed as follows — Not approved or studied in cats: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Verdinexor need a prescription?
Yes. Verdinexor is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database