Thiol compound that undergoes thiol-disulfide exchange with cystine, forming a more soluble tiopronin-cysteine mixed disulfide that is readily excreted in urine. Reduces urinary cystine concentration, preventing cystine urolith formation.
At a glance
Class
Thiol Compound / Cystine-Reducing Agent
Storage
Store at room temperature below 25°C
Dosing
Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds,
Feline cystinuria is extremely rare
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Urinary cystine concentration or cystine:creatinine ratioUrinalysis (crystals, protein)Renal functionCBC
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Tiopronin?
Tiopronin is a thiol compound / cystine-reducing agent used in pets. Thiol compound that undergoes thiol-disulfide exchange with cystine, forming a more soluble tiopronin-cysteine mixed disulfide that is readily excreted in urine. Reduces urinary cystine concentration, preventing cystine urolith formation.
›What is Tiopronin used for in pets?
Tiopronin is used in veterinary medicine for: Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds, ; Feline cystinuria is extremely rare.
›What is the Tiopronin dose for dogs?
For dogs, Tiopronin is typically dosed as follows — Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds, : 15–20 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Tiopronin dose for cats?
For cats, Tiopronin is typically dosed as follows — Feline cystinuria is extremely rare: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Tiopronin need a prescription?
Yes. Tiopronin is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database