Thiol compound that undergoes thiol-disulfide exchange with cystine, forming a more soluble tiopronin-cysteine mixed disulfide that is readily excreted in urine. Reduces urinary cystine concentration, preventing cystine urolith formation.
At a glance
Class
Thiol Compound / Cystine-Reducing Agent
Storage
Store at room temperature below 25°C
Dosing
Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds,
Feline cystinuria is extremely rare
Safety
Urinary cystine concentration or cystine:creatinine ratioUrinalysis (crystals, protein)Renal functionCBC
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Tiopronin?
Tiopronin is a thiol compound / cystine-reducing agent used in pets. Thiol compound that undergoes thiol-disulfide exchange with cystine, forming a more soluble tiopronin-cysteine mixed disulfide that is readily excreted in urine. Reduces urinary cystine concentration, preventing cystine urolith formation.
›What is Tiopronin used for in pets?
Tiopronin is used in veterinary medicine for: Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds, ; Feline cystinuria is extremely rare.
›What is the Tiopronin dose for dogs?
For dogs, Tiopronin is typically dosed as follows — Used for cystinuria/cystine urolithiasis prevention (Newfoundlands, Dachshunds, : 15–20 mg/kg PO q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Tiopronin dose for cats?
For cats, Tiopronin is typically dosed as follows — Feline cystinuria is extremely rare: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Tiopronin need a prescription?
Yes. Tiopronin is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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