Diterpene ester extracted from Fontainea picrosperma (blushwood tree) seeds. Activates protein kinase C, disrupting tumor vasculature and cellular integrity, causing rapid hemorrhagic necrosis of injected tumors within 24h. Also stimulates anti-tumor immune response.
At a glance
Class
Protein Kinase C Activator / Oncolytic
Storage
Refrigerate 2–8°C; protect from light; single-use vials
Dosing
FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous
Frequency
Once; may repeat once at 4 weeks
Not approved or studied in cats
Safety
Tumor response at 7 and 28 daysWound healingSigns of mast cell degranulation (hypotension, GI signs)Antihistamine pre-treatment complianceInfection at wound site
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Tigilanol Tiglate?
Tigilanol Tiglate is a protein kinase c activator / oncolytic used in pets. Diterpene ester extracted from Fontainea picrosperma (blushwood tree) seeds. Activates protein kinase C, disrupting tumor vasculature and cellular integrity, causing rapid hemorrhagic necrosis of injected tumors within 24h. Also stimulates anti-tumor immune response.
›What is Tigilanol Tiglate used for in pets?
Tigilanol Tiglate is used in veterinary medicine for: FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous ; Not approved or studied in cats.
›What is the Tigilanol Tiglate dose for dogs?
For dogs, Tigilanol Tiglate is typically dosed as follows — FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous : undefined undefined PO Once; may repeat once at 4 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Tigilanol Tiglate dose for cats?
For cats, Tigilanol Tiglate is typically dosed as follows — Not approved or studied in cats: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Tigilanol Tiglate need a prescription?
Yes. Tigilanol Tiglate is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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