Diterpene ester extracted from Fontainea picrosperma (blushwood tree) seeds. Activates protein kinase C, disrupting tumor vasculature and cellular integrity, causing rapid hemorrhagic necrosis of injected tumors within 24h. Also stimulates anti-tumor immune response.
At a glance
Class
Protein Kinase C Activator / Oncolytic
Storage
Refrigerate 2–8°C; protect from light; single-use vials
Dosing
FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous
Frequency
Once; may repeat once at 4 weeks
Not approved or studied in cats
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Tumor response at 7 and 28 daysWound healingSigns of mast cell degranulation (hypotension, GI signs)Antihistamine pre-treatment complianceInfection at wound site
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Tigilanol Tiglate?
Tigilanol Tiglate is a protein kinase c activator / oncolytic used in pets. Diterpene ester extracted from Fontainea picrosperma (blushwood tree) seeds. Activates protein kinase C, disrupting tumor vasculature and cellular integrity, causing rapid hemorrhagic necrosis of injected tumors within 24h. Also stimulates anti-tumor immune response.
›What is Tigilanol Tiglate used for in pets?
Tigilanol Tiglate is used in veterinary medicine for: FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous ; Not approved or studied in cats.
›What is the Tigilanol Tiglate dose for dogs?
For dogs, Tigilanol Tiglate is typically dosed as follows — FDA-approved for non-metastatic canine cutaneous mast cell tumors (subcutaneous : undefined undefined PO Once; may repeat once at 4 weeks. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Tigilanol Tiglate dose for cats?
For cats, Tigilanol Tiglate is typically dosed as follows — Not approved or studied in cats: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Tigilanol Tiglate need a prescription?
Yes. Tigilanol Tiglate is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database