Complex mechanism including: inhibition of TNF-α production, stimulation of T-cell proliferation (immunostimulation), inhibition of angiogenesis (anti-VEGF), and modulation of cytokine balance. Teratogenic — causes characteristic limb defects in developing embryos.
At a glance
Class
Immunomodulatory Agent / Anti-angiogenic
Storage
Store at room temperature; handle with gloves; pregnancy prevention program (STEPS) required for human use
Dosing
Off-label use for hemangiosarcoma (anti-angiogenic), refractory mast cell tumors
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
CBC monthlyNeurological exam (peripheral neuropathy)Clinical response to anti-tumor therapyAssess sedation level and quality of life
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Thalidomide?
Thalidomide is a immunomodulatory agent / anti-angiogenic used in pets. Complex mechanism including: inhibition of TNF-α production, stimulation of T-cell proliferation (immunostimulation), inhibition of angiogenesis (anti-VEGF), and modulation of cytokine balance. Teratogenic — causes characteristic limb defects in developing embryos.
›What is Thalidomide used for in pets?
Thalidomide is used in veterinary medicine for: Off-label use for hemangiosarcoma (anti-angiogenic), refractory mast cell tumors; Rarely used in cats.
›What is the Thalidomide dose for dogs?
For dogs, Thalidomide is typically dosed as follows — Off-label use for hemangiosarcoma (anti-angiogenic), refractory mast cell tumors: 2–10 mg/kg PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Thalidomide dose for cats?
For cats, Thalidomide is typically dosed as follows — Rarely used in cats: 5–10 mg/cat PO q24h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Thalidomide need a prescription?
Yes. Thalidomide is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database