Inhibits both cyclooxygenase (COX) and 5-lipoxygenase (LOX) pathways, providing broader anti-inflammatory coverage than COX-only NSAIDs by also blocking leukotriene synthesis
At a glance
Class
Dual COX/LOX inhibitor (NSAID)
Storage
Store below 25°C, protect from moisture; keep in foil blister until use
Dosing
Osteoarthritis pain and inflammation
Frequency
SID (loading dose day 1: 20 mg/kg, then 10 mg/kg)
Duration: Long-term; rapidly-disintegrating tablet on tongue
Not recommended
Duration: Not approved or recommended for cats
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Absolute contraindications — do not use
Adverse effects
Common
Vomiting
Diarrhoea
Anorexia
Serious
GI ulceration/perforation
Hepatotoxicity
Renal injury
Renal valuesHepatic enzymesGI signsCBC
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Tepoxalin?
Tepoxalin is a dual cox/lox inhibitor (nsaid) used in pets. Inhibits both cyclooxygenase (COX) and 5-lipoxygenase (LOX) pathways, providing broader anti-inflammatory coverage than COX-only NSAIDs by also blocking leukotriene synthesis
›What is Tepoxalin used for in pets?
Tepoxalin is used in veterinary medicine for: Osteoarthritis pain and inflammation; Not recommended.
›What is the Tepoxalin dose for dogs?
For dogs, Tepoxalin is typically dosed as follows — Osteoarthritis pain and inflammation: 10–20 mg/kg PO SID (loading dose day 1: 20 mg/kg, then 10 mg/kg). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Tepoxalin dose for cats?
For cats, Tepoxalin is typically dosed as follows — Not recommended: 0 mg/kg N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Tepoxalin?
Common: Vomiting, Diarrhoea, Anorexia. Serious (call your vet immediately): GI ulceration/perforation, Hepatotoxicity, Renal injury.
›Does Tepoxalin need a prescription?
Yes. Tepoxalin is a prescription medication and should only be administered under veterinary supervision.
›When should Tepoxalin not be used?
Do not use Tepoxalin if: Cats; GI ulceration or bleeding; Concurrent corticosteroids or other NSAIDs.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database