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Tacrolimus (Ophthalmic)

Prescription
Calcineurin Inhibitor (Immunomodulator)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
3 available
Formulations
2

Mechanism of action

Binds to FKBP-12, forming a complex that inhibits calcineurin phosphatase, thereby blocking T-lymphocyte activation and cytokine production (IL-2, IL-4). Suppresses local immune-mediated inflammation in KCS.

At a glance

Class
Calcineurin Inhibitor (Immunomodulator)
Schedule
Prescription
Storage
Compounded ointments typically refrigerated; check compounding pharmacy instructions

Dosing

🐕

Dog

Gold standard for immune-mediated KCS and pannus (chronic superficial keratitis)
Dose
Route
Ophthalmic
Frequency
q12h
🐈

Cat

Used for immune-mediated conjunctivitis and eosinophilic keratitis
Dose
Route
Ophthalmic
Frequency
q12h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Compounded ointments typically refrigerated; check compounding pharmacy instructions

Safety

Monitoring parameters

Schirmer Tear Test monthlyCorneal clarity and vascularizationMucus production
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Optimmune (0.02%)
Tacrolivet
Protopic (topical)

FAQs

Frequently asked questions

What is Tacrolimus (Ophthalmic)?
Tacrolimus (Ophthalmic) is a calcineurin inhibitor (immunomodulator) used in pets. Binds to FKBP-12, forming a complex that inhibits calcineurin phosphatase, thereby blocking T-lymphocyte activation and cytokine production (IL-2, IL-4). Suppresses local immune-mediated inflammation in KCS.
What is Tacrolimus (Ophthalmic) used for in pets?
Tacrolimus (Ophthalmic) is used in veterinary medicine for: Gold standard for immune-mediated KCS and pannus (chronic superficial keratitis); Used for immune-mediated conjunctivitis and eosinophilic keratitis.
What is the Tacrolimus (Ophthalmic) dose for dogs?
For dogs, Tacrolimus (Ophthalmic) is typically dosed as follows — Gold standard for immune-mediated KCS and pannus (chronic superficial keratitis): undefined undefined Ophthalmic q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Tacrolimus (Ophthalmic) dose for cats?
For cats, Tacrolimus (Ophthalmic) is typically dosed as follows — Used for immune-mediated conjunctivitis and eosinophilic keratitis: undefined undefined Ophthalmic q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Tacrolimus (Ophthalmic) need a prescription?
Yes. Tacrolimus (Ophthalmic) is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database

Related medicines

Other medicines in the same class (Calcineurin Inhibitor).

Cyclosporine
Rx
Binds cyclophilin to form a complex that inhibits calcineurin, blocking T-cell activation and IL-2 production; provides targeted immunomodulation without myelosuppression
dogcat
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