Synergistic combination: sulfadimethoxine inhibits DHPS and ormetoprim inhibits DHFR (same sequential folate blockade as TMP-sulfa). Long half-life allows once-daily dosing. FDA-approved for dogs.
At a glance
Class
Potentiated Sulfonamide Antibiotic
Storage
Store at room temperature below 30°C
Dosing
FDA-approved for canine skin infections and UTIs
Frequency
q24h (after loading)
Sulfadimethoxine alone (Albon) is used in cats for coccidiosis at different dose
Safety
Schirmer tear testCBCUrinalysis (hydration)Hepatic enzymesThyroid function (chronic)
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Sulfadimethoxine/Ormetoprim?
Sulfadimethoxine/Ormetoprim is a potentiated sulfonamide antibiotic used in pets. Synergistic combination: sulfadimethoxine inhibits DHPS and ormetoprim inhibits DHFR (same sequential folate blockade as TMP-sulfa). Long half-life allows once-daily dosing. FDA-approved for dogs.
›What is Sulfadimethoxine/Ormetoprim used for in pets?
Sulfadimethoxine/Ormetoprim is used in veterinary medicine for: FDA-approved for canine skin infections and UTIs; Sulfadimethoxine alone (Albon) is used in cats for coccidiosis at different dose.
›What is the Sulfadimethoxine/Ormetoprim dose for dogs?
For dogs, Sulfadimethoxine/Ormetoprim is typically dosed as follows — FDA-approved for canine skin infections and UTIs: 55 mg/kg PO q24h (after loading). Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Sulfadimethoxine/Ormetoprim dose for cats?
For cats, Sulfadimethoxine/Ormetoprim is typically dosed as follows — Sulfadimethoxine alone (Albon) is used in cats for coccidiosis at different dose: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Sulfadimethoxine/Ormetoprim need a prescription?
Yes. Sulfadimethoxine/Ormetoprim is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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