Sucralfate contains aluminum which chelates tetracyclines, reducing absorption
Management: Administer doxycycline at least 2 hours before sucralfate.
Sucralfate chelates fluoroquinolones, reducing oral bioavailability by up to 90%
Management: Administer enrofloxacin at least 2 hours before sucralfate
Sucralfate requires acidic environment for activation; omeprazole raises gastric pH, reducing sucralfate efficacy
Management: Administer sucralfate 30-60 minutes before omeprazole if both required.
Sucralfate binds thyroid hormone in the gut, reducing levothyroxine absorption
Management: Give levothyroxine at least 4 hours before sucralfate.
Sucralfate (aluminum-containing) chelates fluoroquinolones, reducing absorption by 50-90%.
Management: Separate by 2 hours. Give marbofloxacin 2h before or 4h after sucralfate.
Sucralfate (aluminum) chelates ciprofloxacin, reducing absorption by 50-90%.
Management: Separate by 2 hours. Give ciprofloxacin 2h before or 4h after sucralfate.
Sucralfate (aluminum) chelates tetracyclines in the GI tract, reducing minocycline absorption. However, minocycline is less affected than other tetracyclines due to high lipophilicity.
Management: Separate by 2 hours if possible. Minocycline absorption is less affected by food/antacids than other tetracyclines, but sucralfate still reduces it.
Aluminum in sucralfate chelates tetracycline, reducing absorption by 50-80%.
Management: Separate by at least 2 hours. Give tetracycline 2h before sucralfate.