Cationic hydrogel polymer that binds dietary phosphorus via ionic and hydrogen bonding in the GI tract. Not absorbed — no systemic metal or calcium loading. Also binds bile acids (lowers LDL cholesterol) and endotoxin.
At a glance
Class
Non-Calcium Non-Aluminum Phosphate Binder (Polymer)
Storage
Store at room temperature, protect from moisture
Dosing
Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an
Frequency
Divided with each meal
Renvela powder formulation easier to mix into cat food than tablets
Frequency
Divided with meals
Safety
Serum phosphorus q2–4 weeksSerum bicarbonateGI toleranceEnsure other medications separated by 1h
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Sevelamer?
Sevelamer is a non-calcium non-aluminum phosphate binder (polymer) used in pets. Cationic hydrogel polymer that binds dietary phosphorus via ionic and hydrogen bonding in the GI tract. Not absorbed — no systemic metal or calcium loading. Also binds bile acids (lowers LDL cholesterol) and endotoxin.
›What is Sevelamer used for in pets?
Sevelamer is used in veterinary medicine for: Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an; Renvela powder formulation easier to mix into cat food than tablets.
›What is the Sevelamer dose for dogs?
For dogs, Sevelamer is typically dosed as follows — Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an: 50–100 mg/kg PO Divided with each meal. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Sevelamer dose for cats?
For cats, Sevelamer is typically dosed as follows — Renvela powder formulation easier to mix into cat food than tablets: 50–100 mg/kg PO Divided with meals. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Sevelamer need a prescription?
Yes. Sevelamer is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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