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Sevelamer

Prescription
Non-Calcium Non-Aluminum Phosphate Binder (Polymer)
Last reviewed 21 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
2 available
Formulations
2

Mechanism of action

Cationic hydrogel polymer that binds dietary phosphorus via ionic and hydrogen bonding in the GI tract. Not absorbed — no systemic metal or calcium loading. Also binds bile acids (lowers LDL cholesterol) and endotoxin.

At a glance

Class
Non-Calcium Non-Aluminum Phosphate Binder (Polymer)
Schedule
Prescription
Storage
Store at room temperature, protect from moisture

Dosing

🐕

Dog

Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an
Dose
50–100 mg/kg
Route
PO
Frequency
Divided with each meal
🐈

Cat

Renvela powder formulation easier to mix into cat food than tablets
Dose
50–100 mg/kg
Route
PO
Frequency
Divided with meals
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 2

Strength
Strength

Storage

Store at room temperature, protect from moisture

Safety

Monitoring parameters

Serum phosphorus q2–4 weeksSerum bicarbonateGI toleranceEnsure other medications separated by 1h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Renagel
Renvela

FAQs

Frequently asked questions

What is Sevelamer?
Sevelamer is a non-calcium non-aluminum phosphate binder (polymer) used in pets. Cationic hydrogel polymer that binds dietary phosphorus via ionic and hydrogen bonding in the GI tract. Not absorbed — no systemic metal or calcium loading. Also binds bile acids (lowers LDL cholesterol) and endotoxin.
What is Sevelamer used for in pets?
Sevelamer is used in veterinary medicine for: Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an; Renvela powder formulation easier to mix into cat food than tablets.
What is the Sevelamer dose for dogs?
For dogs, Sevelamer is typically dosed as follows — Used for CKD hyperphosphatemia when calcium-based binders cause hypercalcemia an: 50–100 mg/kg PO Divided with each meal. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Sevelamer dose for cats?
For cats, Sevelamer is typically dosed as follows — Renvela powder formulation easier to mix into cat food than tablets: 50–100 mg/kg PO Divided with meals. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Sevelamer need a prescription?
Yes. Sevelamer is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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