Selamectin (avermectin) activates glutamate-gated chloride channels in parasites causing paralysis. Sarolaner (isoxazoline) blocks GABA and glutamate-gated chloride channels in arthropods. Combined broad-spectrum ecto/endoparasite prevention.
At a glance
Class
Macrocyclic Lactone + Isoxazoline Combination
Dosing
Revolution Plus is for cats only
FDA-approved for cats ≥8 weeks and ≥1
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Flea/tick/mite burdenHeartworm antigen test annuallyFecal exam for intestinal parasites
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Selamectin/Sarolaner?
Selamectin/Sarolaner is a macrocyclic lactone + isoxazoline combination used in pets. Selamectin (avermectin) activates glutamate-gated chloride channels in parasites causing paralysis. Sarolaner (isoxazoline) blocks GABA and glutamate-gated chloride channels in arthropods. Combined broad-spectrum ecto/endoparasite prevention.
›What is Selamectin/Sarolaner used for in pets?
Selamectin/Sarolaner is used in veterinary medicine for: Revolution Plus is for cats only; FDA-approved for cats ≥8 weeks and ≥1.
›What is the Selamectin/Sarolaner dose for dogs?
For dogs, Selamectin/Sarolaner is typically dosed as follows — Revolution Plus is for cats only: undefined undefined N/A N/A. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Selamectin/Sarolaner dose for cats?
For cats, Selamectin/Sarolaner is typically dosed as follows — FDA-approved for cats ≥8 weeks and ≥1: undefined undefined PO Monthly. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Selamectin/Sarolaner need a prescription?
Yes. Selamectin/Sarolaner is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
CDSCO approvals (India) — 1
Selamectin Tropical Solution for veterinary use 60mg /120mg per ml
M/s Pfizer Ltd., Mumbai · Approved 14.01.2009
(I) For the treatment and lasting prevention of flea infestations treatment and control of flea allergy dermatitis preve
Source: CDSCO Veterinary Drug Approval Registry (1969–2026)
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database