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Robenacoxib

PrescriptionCDSCO approved
COX-2 selective NSAID (coxib)
Last reviewed 19 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Interactions
1 documented
Formulations
5

Mechanism of action

Highly selective COX-2 inhibitor at inflamed tissue, sparing COX-1 mediated protective prostaglandins in the GI tract and kidneys; rapid onset of action

At a glance

Class
COX-2 selective NSAID (coxib)
Schedule
Prescription
Storage
Store below 25°C
CDSCO (India)
Vet-approved — 2012-01

Dosing

🐕

Dog

Pain and inflammation (surgical, osteoarthritis)
Dose
1–2 mg/kg
Route
PO, SC
Frequency
SID
Max dose
40 mg
Duration: SC: up to 3 days perioperative; PO: long-term for OA
🐈

Cat

Perioperative pain / Acute musculoskeletal pain
Dose
1–2 mg/kg
Route
PO, SC
Frequency
SID
Max dose
6 mg
Duration: SC: single dose; PO: up to 6 days (labeled); longer off-label with monitoring

Formulations

💊

Tablet — 4

Strength
6mg
Strength
10mg
Strength
20mg
Strength
40mg
💉

Injection — 1

Strength
20mg/mL

Storage

Store below 25°C

Safety

Absolute contraindications — do not use

  • GI ulceration or bleeding
  • Severe renal or hepatic impairment
  • Concurrent corticosteroids or other NSAIDs
    PrednisoloneMeloxicamCarprofen

Use with caution

  • Dehydration or hypovolemia
    Correct fluid status first

Adverse effects

Common
Vomiting
Diarrhoea
Soft stools
Serious
GI ulceration
Renal injury
Hepatotoxicity

Monitoring parameters

Renal values (BUN, creatinine)Hepatic enzymesGI signsHydration status

Interactions

Contraindicated — 1

Meloxicam
contraindicated
Two NSAIDs: additive prostaglandin inhibition causing GI hemorrhage and renal failure.
Management: Never combine. Allow 3-5 day washout when switching NSAIDs.

Brands

International

Onsior
Elanco

FAQs

Frequently asked questions

›What is Robenacoxib?
Robenacoxib is a cox-2 selective nsaid (coxib) used in pets. Highly selective COX-2 inhibitor at inflamed tissue, sparing COX-1 mediated protective prostaglandins in the GI tract and kidneys; rapid onset of action
›What is Robenacoxib used for in pets?
Robenacoxib is used in veterinary medicine for: Pain and inflammation (surgical, osteoarthritis); Perioperative pain / Acute musculoskeletal pain.
›What is the Robenacoxib dose for dogs?
For dogs, Robenacoxib is typically dosed as follows — Pain and inflammation (surgical, osteoarthritis): 1–2 mg/kg PO/SC SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Robenacoxib dose for cats?
For cats, Robenacoxib is typically dosed as follows — Perioperative pain / Acute musculoskeletal pain: 1–2 mg/kg PO/SC SID. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What are the side effects of Robenacoxib?
Common: Vomiting, Diarrhoea, Soft stools. Serious (call your vet immediately): GI ulceration, Renal injury, Hepatotoxicity.
›Does Robenacoxib need a prescription?
Yes. Robenacoxib is a prescription medication and should only be administered under veterinary supervision.
›When should Robenacoxib not be used?
Do not use Robenacoxib if: GI ulceration or bleeding; Severe renal or hepatic impairment; Concurrent corticosteroids or other NSAIDs.

References

References

Textbooks & handbooks

  • Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
  • Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
  • Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
  • National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
  • The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/

Clinical guidelines & consensus

  • Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
  • American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.

Journals & peer-reviewed studies

  • Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
  • Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
  • ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control

Regulatory & approvals

  • Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/

Databases

  • Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →