Recombinant fungal urate oxidase enzyme that catalyzes the oxidation of uric acid to allantoin (a more soluble and easily excreted metabolite), rapidly reducing plasma uric acid levels. Used for tumor lysis syndrome.
At a glance
Class
Recombinant Urate Oxidase / Antihyperuricemic
Storage
Refrigerate 2–8°C; diluted solution stable 24h refrigerated; do not shake
Dosing
Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep
Route
IV (over 30 minutes)
Frequency
Once daily for duration of risk
Limited veterinary feline data
Safety
Serum uric acid levelsRenal functionCBCSigns of hypersensitivity during infusion
Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Rasburicase?
Rasburicase is a recombinant urate oxidase / antihyperuricemic used in pets. Recombinant fungal urate oxidase enzyme that catalyzes the oxidation of uric acid to allantoin (a more soluble and easily excreted metabolite), rapidly reducing plasma uric acid levels. Used for tumor lysis syndrome.
›What is Rasburicase used for in pets?
Rasburicase is used in veterinary medicine for: Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep; Limited veterinary feline data.
›What is the Rasburicase dose for dogs?
For dogs, Rasburicase is typically dosed as follows — Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep: 0.05–0.2 mg/kg IV (over 30 minutes) Once daily for duration of risk. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Rasburicase dose for cats?
For cats, Rasburicase is typically dosed as follows — Limited veterinary feline data: 0.05–0.2 mg/kg IV Once daily. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Rasburicase need a prescription?
Yes. Rasburicase is a prescription medication and should only be administered under veterinary supervision.
References
References
Textbooks & handbooks
- Plumb, D.C. Plumb's Veterinary Drug Handbook. 10th ed., Wiley-Blackwell, 2023.
- Vail, D.M., Thamm, D.H., & Liptak, J.M. (eds.). Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed., Saunders/Elsevier, 2020.
- Riviere, J.E., & Papich, M.G. (eds.). Veterinary Pharmacology and Therapeutics. 10th ed., Wiley-Blackwell, 2018.
- National Research Council. Nutrient Requirements of Dogs and Cats. National Academies Press, Washington DC, 2006.
- The Merck Veterinary Manual. Merck & Co., Online edition. https://www.merckvetmanual.com/
Clinical guidelines & consensus
- Fletcher, D.J., Boller, M., Brainard, B.M., et al. "RECOVER Evidence and Knowledge Gap Analysis on Veterinary CPR." Journal of Veterinary Emergency and Critical Care, 2012;22(S1):S102–S131.
- American Animal Hospital Association. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. AAHA Press.
Journals & peer-reviewed studies
- Hogan, D.F., Fox, P.R., Jacob, K., et al. "Secondary prevention of cardiogenic arterial thromboembolism in the cat: The FAT CAT study." Journal of Veterinary Cardiology, 2015;17(Suppl 1):S306–S317.
- Boswood, A., Häggström, J., Gordon, S.G., et al. "Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study — A Randomized Clinical Trial." Journal of Veterinary Internal Medicine, 2016;30(6):1765–1779.
- ASPCA Animal Poison Control Center. Toxicology and Poison Management Guidelines. American Society for the Prevention of Cruelty to Animals. https://www.aspca.org/pet-care/animal-poison-control
Regulatory & approvals
- Central Drugs Standard Control Organisation (CDSCO), Government of India. Veterinary Drug Approval Registry, 1969–2026. Directorate General of Health Services. https://cdsco.gov.in/
Databases
- Washington State University, College of Veterinary Medicine. Veterinary Clinical Pharmacology Laboratory (VCPL) — MDR1 Multidrug Sensitivity Database. https://vcpl.vetmed.wsu.edu/
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
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