Recombinant fungal urate oxidase enzyme that catalyzes the oxidation of uric acid to allantoin (a more soluble and easily excreted metabolite), rapidly reducing plasma uric acid levels. Used for tumor lysis syndrome.
At a glance
Class
Recombinant Urate Oxidase / Antihyperuricemic
Storage
Refrigerate 2–8°C; diluted solution stable 24h refrigerated; do not shake
Dosing
Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep
Route
IV (over 30 minutes)
Frequency
Once daily for duration of risk
Limited veterinary feline data
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Serum uric acid levelsRenal functionCBCSigns of hypersensitivity during infusion
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Rasburicase?
Rasburicase is a recombinant urate oxidase / antihyperuricemic used in pets. Recombinant fungal urate oxidase enzyme that catalyzes the oxidation of uric acid to allantoin (a more soluble and easily excreted metabolite), rapidly reducing plasma uric acid levels. Used for tumor lysis syndrome.
›What is Rasburicase used for in pets?
Rasburicase is used in veterinary medicine for: Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep; Limited veterinary feline data.
›What is the Rasburicase dose for dogs?
For dogs, Rasburicase is typically dosed as follows — Used in chemotherapy-induced tumor lysis syndrome (TLS) to prevent uric acid nep: 0.05–0.2 mg/kg IV (over 30 minutes) Once daily for duration of risk. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Rasburicase dose for cats?
For cats, Rasburicase is typically dosed as follows — Limited veterinary feline data: 0.05–0.2 mg/kg IV Once daily. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Rasburicase need a prescription?
Yes. Rasburicase is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database