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Propantheline

Prescription
Quaternary Ammonium Anticholinergic / Antispasmodic
Last reviewed 22 Apr 2026 · PetCare.AI Editorial Team
Species
Dog, Cat
Brands
1 available
Formulations
1

Mechanism of action

Synthetic quaternary ammonium antimuscarinic that blocks muscarinic receptors in smooth muscle, reducing GI motility and urinary bladder detrusor contractions. Does not cross BBB (quaternary structure — no CNS effects).

At a glance

Class
Quaternary Ammonium Anticholinergic / Antispasmodic
Schedule
Prescription
Storage
Store at room temperature below 30°C

Dosing

🐕

Dog

Used for urge urinary incontinence (detrusor hyperreflexia), GI spasm, and irrit
Dose
0.25–0.5 mg/kg
Route
PO
Frequency
q8–12h
🐈

Cat

Used for feline detrusor instability
Dose
Route
PO
Frequency
q72h
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Formulations

💊

Other — 1

Strength

Storage

Store at room temperature below 30°C

Safety

Monitoring parameters

Urinary frequency/incontinenceUrine output (retention)GI motilityHeart rate
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

Interactions

No documented interactions.

Brands

Other markets

Pro-Banthine

FAQs

Frequently asked questions

What is Propantheline?
Propantheline is a quaternary ammonium anticholinergic / antispasmodic used in pets. Synthetic quaternary ammonium antimuscarinic that blocks muscarinic receptors in smooth muscle, reducing GI motility and urinary bladder detrusor contractions. Does not cross BBB (quaternary structure — no CNS effects).
What is Propantheline used for in pets?
Propantheline is used in veterinary medicine for: Used for urge urinary incontinence (detrusor hyperreflexia), GI spasm, and irrit; Used for feline detrusor instability.
What is the Propantheline dose for dogs?
For dogs, Propantheline is typically dosed as follows — Used for urge urinary incontinence (detrusor hyperreflexia), GI spasm, and irrit: 0.25–0.5 mg/kg PO q8–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
What is the Propantheline dose for cats?
For cats, Propantheline is typically dosed as follows — Used for feline detrusor instability: undefined undefined PO q72h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
Does Propantheline need a prescription?
Yes. Propantheline is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet. Find a vet near you →

References

References

The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.

Textbooks & handbooks — 5

  • Plumb's Veterinary Drug Handbook
  • Withrow & MacEwen's Small Animal Clinical Oncology
  • Merck Veterinary Manual
  • NRC Nutrient Requirements of Dogs and Cats
  • Veterinary Pharmacology and Therapeutics (Riviere & Papich)

Clinical guidelines & consensus — 4

  • ASPCA Animal Poison Control Center Guidelines
  • AAHA Diabetes Management Guidelines
  • ASPCA Poison Control Guidelines
  • RECOVER CPR Guidelines

Journals & peer-reviewed studies — 2

  • EPIC Study (J Vet Intern Med 2016)
  • JVIM FAT CAT Study

Regulatory & approvals — 1

  • CDSCO Veterinary Drug Approval Registry (1969–2026)

Databases — 1

  • Washington State University VCPL MDR1 Database
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