First-generation phenothiazine antihistamine that blocks H1 receptors, muscarinic receptors, and dopamine D2 receptors. Potent antiemetic (CTZ blockade), sedative, and antipruritic. Also has local anesthetic properties.
At a glance
Class
Phenothiazine Antihistamine / Antiemetic
Storage
Store at room temperature, protect from light
Dosing
Used for motion sickness, nausea/vomiting, and allergic conditions
Used for antiemetic and antihistamine effects
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Antiemetic efficacySedation levelIV site (if IV used — slow push only)
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Promethazine?
Promethazine is a phenothiazine antihistamine / antiemetic used in pets. First-generation phenothiazine antihistamine that blocks H1 receptors, muscarinic receptors, and dopamine D2 receptors. Potent antiemetic (CTZ blockade), sedative, and antipruritic. Also has local anesthetic properties.
›What is Promethazine used for in pets?
Promethazine is used in veterinary medicine for: Used for motion sickness, nausea/vomiting, and allergic conditions; Used for antiemetic and antihistamine effects.
›What is the Promethazine dose for dogs?
For dogs, Promethazine is typically dosed as follows — Used for motion sickness, nausea/vomiting, and allergic conditions: 0.2–0.5 mg/kg PO/IM/IV (slow) q8–12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Promethazine dose for cats?
For cats, Promethazine is typically dosed as follows — Used for antiemetic and antihistamine effects: 0.2–0.5 mg/kg PO/IM q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Promethazine need a prescription?
Yes. Promethazine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database