Blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ), providing potent antiemetic effects. Also blocks histaminergic and cholinergic receptors. More potent antiemetic than metoclopramide for centrally-mediated vomiting.
At a glance
Class
Phenothiazine Antiemetic
Storage
Store at room temperature, protect from light
Dosing
Used for severe nausea/vomiting (chemotherapy-induced, pancreatitis, gastroenter
Used for severe feline vomiting
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Safety
Emesis controlBlood pressureSedation level
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →Interactions
No documented interactions.
FAQs
Frequently asked questions
›What is Prochlorperazine?
Prochlorperazine is a phenothiazine antiemetic used in pets. Blocks dopamine D2 receptors in the chemoreceptor trigger zone (CTZ), providing potent antiemetic effects. Also blocks histaminergic and cholinergic receptors. More potent antiemetic than metoclopramide for centrally-mediated vomiting.
›What is Prochlorperazine used for in pets?
Prochlorperazine is used in veterinary medicine for: Used for severe nausea/vomiting (chemotherapy-induced, pancreatitis, gastroenter; Used for severe feline vomiting.
›What is the Prochlorperazine dose for dogs?
For dogs, Prochlorperazine is typically dosed as follows — Used for severe nausea/vomiting (chemotherapy-induced, pancreatitis, gastroenter: 0.1–0.5 mg/kg IM/SQ/PO q6–8h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›What is the Prochlorperazine dose for cats?
For cats, Prochlorperazine is typically dosed as follows — Used for severe feline vomiting: 0.1–0.5 mg/kg IM/SQ q12h. Always consult your veterinarian for a dose tailored to your pet's weight, age, and condition.
›Does Prochlorperazine need a prescription?
Yes. Prochlorperazine is a prescription medication and should only be administered under veterinary supervision.
Educational reference only
This information is provided for educational purposes and is not a substitute for professional veterinary advice, diagnosis, or treatment. Always consult a qualified veterinarian before administering any medication to your pet.
Find a vet near you →References
References
The PetCare.AI drug reference is built from 13 authoritative sources cited across 580 drug monographs.
Textbooks & handbooks — 5
- Plumb's Veterinary Drug Handbook
- Withrow & MacEwen's Small Animal Clinical Oncology
- Merck Veterinary Manual
- NRC Nutrient Requirements of Dogs and Cats
- Veterinary Pharmacology and Therapeutics (Riviere & Papich)
Clinical guidelines & consensus — 4
- ASPCA Animal Poison Control Center Guidelines
- AAHA Diabetes Management Guidelines
- ASPCA Poison Control Guidelines
- RECOVER CPR Guidelines
Journals & peer-reviewed studies — 2
- EPIC Study (J Vet Intern Med 2016)
- JVIM FAT CAT Study
Regulatory & approvals — 1
- CDSCO Veterinary Drug Approval Registry (1969–2026)
Databases — 1
- Washington State University VCPL MDR1 Database